公开(公告)号：EP1382690A1

公开(公告)日：2004-01-21

申请号：EP02077909.6

申请日：2002-07-17

申请人： Stichting Sanquin Bloedvoorziening

发明人： van Oers, Josephus W. A. M. ,  van der Vorst, Teun J. K. ,  Hack, Cornelis E. ,  van Engelenburg, Franciscus A. C.

IPC分类号： C12Q1/37 ,  G01N33/68

CPC分类号： C12Q1/37 ,  G01N33/6896 ,  G01N2800/2828

摘要： This invention relates to the field of prion diseases. A method is provided to reduce false positive outcomes in a test by monitoring the activity of a proteolytic enzyme in a test sample comprising providing the test sample with a substrate and contacting the enzyme with said substrate to allow conversion of the substrate by the enzyme into a detectable product and detecting said product. Use of a method according to the invention can improve the reliability of prion tests.

摘要翻译： 本发明涉及朊病毒疾病领域。 提供了一种通过监测测试样品中的蛋白水解酶的活性来减少测试中的假阳性结果的方法，包括向测试样品提供底物并使酶与所述底物接触以允许通过酶将底物转化为 可检测的产品并检测所述产品。 使用根据本发明的方法可以提高朊病毒试验的可靠性。