公开(公告)号：EP1027066A1

公开(公告)日：2000-08-16

申请号：EP98952256.0

申请日：1998-10-13

申请人： Sunol Molecular Corporation

发明人： RHODE, Peter, R. ,  ACEVEDO, Jorge ,  BURKHARDT, Martin ,  JIAO, Jin-an ,  WONG, Hing, C.

IPC分类号： A61K38/00 ,  C07K14/74 ,  C12N15/09 ,  C12N15/12

CPC分类号： C07K14/70539 ,  A61K38/00 ,  C07K2319/00 ,  C12N2799/026

摘要： The present invention relates to novel complexes of major histocompatibility complexe (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II β2 chain modification, e.g., deletion of essentially the entire class II β2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.