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公开(公告)号：EP0975672A1
公开(公告)日：2000-02-02
申请号：EP98910277.7
申请日：1998-03-10
CPC分类号： C07K16/36 , A61K38/00 , A61K39/395 , A61K2300/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF: VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
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2.发明公开BINDING MOLECULES AND COMPUTER-BASED METHODS OF INCREASING THE BINDING AFFINITY THEREOF 失效结合分子和基于计算机的方法用于增加的结合亲和力
公开(公告)号：EP0874899A1
公开(公告)日：1998-11-04
申请号：EP97909909.0
申请日：1997-09-30
CPC分类号： C07K16/36 , C07K16/00 , C07K2319/00
摘要： The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.
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3.发明公开
公开(公告)号：EP1446157A2
公开(公告)日：2004-08-18
申请号：EP02793851.3
申请日：2002-10-29
IPC分类号： A61K39/395 , C07K16/36
CPC分类号： C07K16/36 , A61K2039/505 , C07K16/467 , C07K2317/24 , C07K2319/00
摘要： The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:FVIIa complex, effectively preventing factor X or FIX binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site. Also provided are humanized antibodies and fragments thereof that bind to the TF.
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4.发明公开
公开(公告)号：EP1223921A2
公开(公告)日：2002-07-24
申请号：EP00973964.0
申请日：2000-10-27
发明人： JIAO, Jin-An , LEUPSCHEN, Lawrence, K. , NIEVES, Esperanza, L. , WONG, Hing, C. , TAYLOR, Dean, P.
IPC分类号： A61K31/00
CPC分类号： A61K31/663 , A61K31/00 , A61K31/137 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/196 , A61K31/381 , A61K31/415 , A61K31/4192 , A61K31/423 , A61K31/4704 , A61K31/473 , A61K31/495 , A61K31/506 , A61K45/06 , C07C217/30 , C07C251/24 , C07C275/40 , C07C2601/02 , C07C2601/08 , C07F9/3873 , Y10S514/888
摘要： The invention includes tissue factor (TF) blocking compounds and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such compounds. Compounds of the invention are particularly useful for treating or prophylaxis of undesired thrombosis.
摘要翻译： 本发明包括使用或包含一种或多种这样的化合物的药学活性化合物和治疗方法以及药物组合物。 本发明的化合物特别可用于治疗或预防不期望的血栓形成。
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公开(公告)号：EP1124568A1
公开(公告)日：2001-08-22
申请号：EP99970601.3
申请日：1999-10-21
IPC分类号： A61K35/26 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2809 , A61K2039/505 , C07K14/7051 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.
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公开(公告)号：EP1137808B1
公开(公告)日：2004-09-29
申请号：EP99961864.8
申请日：1999-11-30
CPC分类号： C12N15/67 , C07K16/2896 , C07K2317/24 , C07K2319/00 , C12N15/65
摘要： Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.
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公开(公告)号：EP1137808A1
公开(公告)日：2001-10-04
申请号：EP99961864.8
申请日：1999-11-30
IPC分类号： C12Q1/68
CPC分类号： C12N15/67 , C07K16/2896 , C07K2317/24 , C07K2319/00 , C12N15/65
摘要： Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.
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公开(公告)号：EP1027066A1
公开(公告)日：2000-08-16
申请号：EP98952256.0
申请日：1998-10-13
CPC分类号： C07K14/70539 , A61K38/00 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to novel complexes of major histocompatibility complexe (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II β2 chain modification, e.g., deletion of essentially the entire class II β2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.
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公开(公告)号：EP1019439A1
公开(公告)日：2000-07-19
申请号：EP98949572.6
申请日：1998-09-28
IPC分类号： C07K14/725 , A61K38/00 , A61K39/00
CPC分类号： C07K14/7051 , A61K38/00 , C07K2319/00 , C07K2319/30
摘要： The present invention features fully soluble and functional single-chain T-cell receptor proteins. In one aspect, the invention features soluble fusion proteins comprising an immunoglobin light chain constant region or fragment thereof covalently linked to a single-chain T-cell receptor, wherein the single-chain T-cell receptor comprises a V-α chain covalently linked to a V-β chain by a peptide linker sequence. The single-chain T-cell receptor proteins have a variety of uses including use in screens to detect cells expressly desired MHC-peptide complexes.
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公开(公告)号：EP0997477A2
公开(公告)日：2000-05-03
申请号：EP99124343.7
申请日：1995-07-31
发明人： Wong, Hing C. , Rhode, Peter R. , Weidanz, Jon A. , Grammer, Susan , Edwards, Ann C. , Chavaillaz, Pierre-Andre , Jiao, Jin-An
CPC分类号： C07K14/77 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C07K14/70532 , C07K14/70539 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain an MHC molecule with a peptided-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.
摘要翻译： 本发明涉及主要组织相容性复合物（MHC）分子的新型复合物和这种复合物的用途。 特别地，本发明涉及MHC融合复合物，其含有具有肽结合槽的MHC分子和与MHC蛋白共价连接的呈递肽。 本发明的融合复合物可用于各种应用，包括用于鉴定和分离调节所选T细胞活性的肽的体外筛选，包括作为T细胞受体拮抗剂和部分激动剂的肽，抑制a的免疫应答的方法 哺乳动物和在哺乳动物中诱导免疫应答的方法。
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