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1.发明授权
公开(公告)号：EP2730572B1
公开(公告)日：2015-09-16
申请号：EP12811420.4
申请日：2012-07-09
发明人： ZHANG, Jiancun , ZHANG, Yingjun , XIE, Hongming , REN, Qingyun , LUO, Huichao , YU, Tianzhu , TAN, Yumei
IPC分类号： C07D403/14 , C07D405/14 , C07D401/14 , C07D409/14 , C07D471/04 , A61K31/4178 , A61K31/4439 , A61K31/438 , A61K31/4184 , A61K31/4745 , A61P1/16 , A61P31/14
CPC分类号： C07K5/06052 , A61K38/05 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
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2.发明公开BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF 有权桥环化合物作为丙型肝炎病毒（HCV）抑制剂和药物应用THEREOF
公开(公告)号：EP2880030A1
公开(公告)日：2015-06-10
申请号：EP13824843.0
申请日：2013-08-05
发明人： ZHANG, Yingjun , ZHANG, Jiancun , XIE, Hongming , REN, Qingyun , TAN, Yumei , LUO, Huichao
IPC分类号： C07D403/14 , C07D401/14 , A61K31/4178 , A61K31/4025 , A61P31/12
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/439 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/06 , C07D471/08 , C07D491/056 , C07D491/113 , C07D493/08 , C07D519/00
摘要： Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.
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3.发明授权BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF 有权桥环化合物作为丙型肝炎病毒（HCV）抑制剂及其药物应用
公开(公告)号：EP2880030B1
公开(公告)日：2018-01-10
申请号：EP13824843.0
申请日：2013-08-05
发明人： ZHANG, Yingjun , ZHANG, Jiancun , XIE, Hongming , REN, Qingyun , TAN, Yumei , LUO, Huichao
IPC分类号： C07D403/14 , C07D401/14 , A61K31/4178 , A61K31/4025 , A61P31/12 , C07D405/14
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/439 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/06 , C07D471/08 , C07D491/056 , C07D491/113 , C07D493/08 , C07D519/00
摘要： Provided herein is a compound having Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, which can be used for treating HCV infection or a HCV disorder. Also provided herein are pharmaceutical compositions comprising the compounds disclosed herein, which can be used for treating HCV infection or a HCV disorder.
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公开(公告)号：EP2730572A1
公开(公告)日：2014-05-14
申请号：EP12811420.4
申请日：2012-07-09
发明人： ZHANG, Jiancun , ZHANG, Yingjun , XIE, Hongming , REN, Qingyun , LUO, Huichao , YU, Tianzhu , TAN, Yumei
IPC分类号： C07D403/14 , C07D405/14 , C07D401/14 , C07D409/14 , C07D471/04 , A61K31/4178 , A61K31/4439 , A61K31/438 , A61K31/4184 , A61K31/4745 , A61P1/16 , A61P31/14
CPC分类号： C07K5/06052 , A61K38/05 , A61K45/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D471/04
摘要： Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.
摘要翻译： 公开了式（I）的螺环化合物，或其立体异构体，几何异构体，互变异构体，氮氧化物，水合物，溶剂化物，代谢物，药学上可接受的盐或前药。 该化合物可用于治疗丙型肝炎病毒（HCV）感染或丙型肝炎疾病。 还公开了含有该化合物的药物组合物以及使用该化合物或药物组合物治疗HCV感染或丙型肝炎疾病的方法。
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