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1.发明授权FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS 有权Kondensierte Cyclooctylverbindungen und ihre Verwendung in metallfreien Click-Reaktionen
公开(公告)号：EP2563753B3
公开(公告)日：2016-01-06
申请号：EP11720197.0
申请日：2011-04-26
申请人： SynAffix B.V.
发明人： VAN DELFT, Floris, Louis , RUTJES, Floris, Petrus, Johannes, Theodorus , DOMMERHOLT, Frederik, Jan
IPC分类号： C07C33/16 , C07C69/96 , A61K47/48 , A61K49/00 , C07C29/147 , C07C29/58 , C07C29/62 , C07C67/347 , C07C271/12 , G01N33/532 , G01N33/58
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
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2.发明授权
公开(公告)号：EP2563753B9
公开(公告)日：2016-07-06
申请号：EP11720197.0
申请日：2011-04-26
申请人： SynAffix B.V.
发明人： VAN DELFT, Floris, Louis , RUTJES, Floris, Petrus, Johannes, Theodorus , DOMMERHOLT, Frederik, Jan
IPC分类号： C07C33/16 , C07C69/96 , A61K47/48 , A61K49/00 , C07C29/147 , C07C29/58 , C07C29/62 , C07C67/347 , C07C271/12 , G01N33/532 , G01N33/58
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
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3.发明授权FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS 有权简明Cyclooctylverbindungen及其在无金属点击反应中的应用
公开(公告)号：EP2563753B1
公开(公告)日：2014-11-05
申请号：EP11720197.0
申请日：2011-04-26
申请人： SynAffix B.V.
发明人： VAN DELFT, Floris, Louis , RUTJES, Floris, Petrus, Johannes, Theodorus , DOMMERHOLT, Frederik, Jan
IPC分类号： C07C33/16 , C07C69/96 , A61K47/48 , A61K49/00 , C07C29/147 , C07C29/58 , C07C29/62 , C07C67/347 , C07C271/12 , G01N33/532 , G01N33/58
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
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4.发明公开FUSED CYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS 有权简明Cyclooctylverbindungen及其在无金属点击反应中的应用
公开(公告)号：EP2563753A1
公开(公告)日：2013-03-06
申请号：EP11720197.0
申请日：2011-04-26
申请人： SynAffix B.V.
发明人： VAN DELFT, Floris, Louis , RUTJES, Floris, Petrus, Johannes, Theodorus , DOMMERHOLT, Frederik, Jan
CPC分类号： C07C33/16 , A61K47/48023 , A61K47/54 , A61K49/0052 , C07C29/147 , C07C29/58 , C07C29/62 , C07C62/30 , C07C67/347 , C07C269/06 , C07C271/12 , C07C271/20 , C07C2602/24 , C07D311/82 , C07D495/04 , C07K14/47 , G01N21/6428 , G01N33/532 , G01N33/582 , G01N33/585 , G01N2021/6439 , C07C33/44 , C07C69/753
摘要： The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label,and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification,of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
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