公开(公告)号：EP2789631A1

公开(公告)日：2014-10-15

申请号：EP13305468.4

申请日：2013-04-10

申请人： Synapse B.V.

发明人： De Laat, Henricus Bastiaan ,  Du, Xiaoyan ,  Ruggeri, Zaverio M.

IPC分类号： C07K16/28 ,  C07K7/08 ,  C07K11/00 ,  A61K38/10

CPC分类号： C07K16/2848 ,  A61K38/1774 ,  A61K2039/505 ,  C07K7/08 ,  C07K14/70525 ,  C07K14/70546 ,  C07K16/2821 ,  G01N33/5044 ,  G01N2500/02

摘要： The present invention relates to compounds and methods for inhibition of binding of ICAM-4 to platelet integrin α IIb β 3 .
The present invention also relates to a screening method and to a kit to detect or monitor in vitro the effect of a substance, drug or pharmaceutical agent on the ICAM-4/α IIb β 3 interaction in a biological sample, while simulating blood flow conditions existing in vivo.
It concerns in particular an anti-ICAM-4 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin α IIb β 3 , or an ICAM-4 mimetic peptide blocking ICAM-4 binding to platelet integrin α IIb β 3 , or an anti-CD61 antibody or a fragment thereof capable of blocking ICAM-4 binding to platelet integrin α IIb β 3 , for use in the treatment of a thrombotic disease, and for the preparation of pharmaceutical compositions for such treatment.

摘要翻译： 本发明涉及的化合物和方法用于抑制整联IIB±ICAM-4结合到血小板²第三 因此，本发明涉及的筛选方法和试剂盒，以检测或监测体外的物质，药物或药剂的对ICAM-4 /±IIB²3的生物样品中的相互作用的效果，同时模拟血液的流动条件 现有的体内。 它尤其涉及到抗ICAM-4抗体或能够阻断ICAM-4结合到血小板整体的片段±IIB²3，或ICAM-4模拟肽阻断ICAM-4结合到血小板整±IIB²3， 或抗CD61抗体或能够阻断ICAM-4结合到血小板整IIB±²3，用于血栓性疾病的治疗中使用的其片段，以及用于制备药物组合物用于寻求治疗的。