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    4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE
    2.
    发明公开
    4,5-DIHYDRONAPHTHO [1,2-b] THIOPHENE DERIVATIVE 审中-公开
    4,5-二氢萘并[1,2-B] THIOPHENDERIVAT

    公开(公告)号：EP1650202A4

    公开(公告)日：2007-04-04

    申请号：EP04771104

    申请日：2004-07-30

    申请人： TAISHO PHARMA CO LTD

    发明人： TAGUCHI MINORU ,  SUZUKI RYO ,  MIKAMI AYAKO

    IPC分类号： C07D333/74 ,  A61K31/381 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  C07D319/18 ,  C07D495/04

    CPC分类号： C07D333/74 ,  C07D319/18 ,  C07D495/04

    摘要： A 4,5-dihydronaphtho[1,2-b]thiophene derivative represented by the formula (1) (wherein R1 represents C1-10 1-hydroxyalkyl or C1-10 acyl, and R2 and R3 are separately bonded in respective positions selected among the 6-, 7-, 8-, and 9-positions and each independently represents hydrogen, halogeno, C1-10 alkyl, hydroxy, C1-10 alkoxy, C1-5 alkenyloxy, C1-5 alkynyloxy, benzyloxy, etc., provided that when R1 is acyl and R2 is hydrogen, then R3 is neither hydrogen nor acetyl) or a pharmaceutically acceptable salt of the derivative. It is a novel compound effective in reducing triglyceride amount in the liver and reducing blood sugar level.