公开(公告)号：EP1985620A1

公开(公告)日：2008-10-29

申请号：EP07706316.2

申请日：2007-02-07

申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Meiji Seika Kaisha Ltd.

发明人： SUGIMOTO, Tomohiro ,  YAMAMOTO, Kanako ,  MANAKA, Akira ,  OGITA, Haruhisa ,  KUROSAKA, Jun ,  KAWAMURA, Madoka ,  KASHIMURA, Masato ,  SASAMOTO, Naoki ,  MIURA, Tomoaki ,  KANEMOTO, Kenichi ,  OZAWA, Tomohiro ,  CHIKAUCHI, Ken ,  SHITARA, Eiki ,  KUBOTA, Dai

IPC分类号： C07H17/00 ,  C07H15/12 ,  A61K31/7052 ,  A61P31/04

CPC分类号： C07H17/00 ,  A61K31/7052

摘要： [Object]: To provide a compound having a novel structure effective against Hemophilus influenzae and erythromycin resistant bacteria (for example, resistant pneumococci and streptococci) as well as against conventional erythromycin sensitive bacteria.
[Solution]: A novel 10a-azalide compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof, or an intermediate for the preparation of the same. The compound of the present invention has superior antibacterial activity against Hemophilus influenzae , erythromycin resistant pneumococci and the like, and therefore, the compound can be used as a therapeutic agent of infectious diseases.

摘要翻译： [目的]提供具有抗血友病流感嗜血杆菌和抗红霉素的细菌（例如耐药性肺炎球菌和链球菌）以及常规红霉素敏感细菌的新型结构的化合物。 [溶液]：由式（I）表示的新型10a-氮杂化合物，其药学上可接受的盐或其溶剂合物或其制备的中间体。 本发明的化合物对流感嗜血杆菌，抗红霉素的肺炎球菌等具有优异的抗菌活性，因此可用作感染性疾病的治疗剂。

公开(公告)号：EP0845463A1

公开(公告)日：1998-06-03

申请号：EP95924522.6

申请日：1995-07-07

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： SATO, Masakazu ,  MANAKA, Akira ,  TAKAHASHI, Keiko ,  KAWASHIMA, Yutaka ,  HATAYAMA, Katsuo

IPC分类号： C07D491/113 ,  A61K31/435

CPC分类号： C07D491/10

摘要： Object: To provide the thiazoline derivatives having an excellent inhibitory action of blood platelet aggregation when administered not only parenterally but also orally.
Constitution: A thiazoline derivative represented by the formula:
(wherein R 1 is an alkyl group having 1 to 4 carbon atoms, and R 2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms) or a pharmaceutically acceptable salt thereof.

摘要翻译： 目的：提供噻唑啉衍生物，其不仅在肠胃外给药而且口服给药时具有优异的血小板聚集抑制作用。 组成：一种由下式表示的噻唑啉衍生物或其药学上可接受的盐：（其中R 1为具有1至4个碳原子的烷基，且R 2为氢原子或具有1至4个碳原子的烷基）。

公开(公告)号：EP0619312A1

公开(公告)日：1994-10-12

申请号：EP93900418.0

申请日：1992-12-18

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： SATO, Masakazu ,  KAWASE, Masahiro ,  MANAKA, Akira ,  KAWASHIMA, Yutaka ,  HATAYAMA, Katsuo

IPC分类号： C07D295/08 ,  C07D213/74 ,  C07D239/42 ,  C07D295/18

CPC分类号： C07D239/42 ,  C07D213/74 ,  C07D295/088 ,  C07D295/112 ,  C07D295/185

摘要： To provide a compound with a potent ACAT inhibiting activity. An anilide derivative represented by general formula (I) and a salt thereof, wherein R¹ and R² may be the same or different from each other and each represents C₁-C₄ alkyl; n represents 0, 1 or 2; A represents C₁-C₁₄ alkylene or -CH₂CO-; and Ar represents phenyl or benzyl each of which may be substituted by halogen, nitro, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₂-C₅ alkanoyl or trifluoromethyl, or pyridyl or pyrimidyl each of which may be substituted by halogen or trifluoromethyl.

摘要翻译： 提供具有强效ACAT抑制活性的化合物。 由通式（I）表示的苯胺衍生物及其盐，其中R 1和R 2可以相同或不同，各自表示C1-C4烷基; n表示0,1或2; A表示C1-C14亚烷基或-CH2CO-; 并且Ar表示可被卤素，硝基，C 1 -C 4烷基，C 1 -C 4烷氧基，C 2 -C 5烷酰基或三氟甲基取代的苯基或苄基，或各自可被卤素或三氟甲基取代的吡啶基或嘧啶基。