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    7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE
    2.
    发明公开
    7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE 有权
    7-哌啶子基-3,4-二氢喹诺酮衍生物

    公开(公告)号：EP2344471A1

    公开(公告)日：2011-07-20

    申请号：EP09817928.6

    申请日：2009-09-30

    申请人： Taisho Pharmaceutical Co., Ltd.

    发明人： KANUMA, Kosuke ,  MIYAKOSHI, Naoki ,  KAWAMURA, Madoka ,  SHIBATA, Tsuyoshi

    IPC分类号： C07D401/06 ,  A61K31/4709 ,  A61P1/14 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P15/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P25/36 ,  A61P43/00 ,  C07D401/14

    CPC分类号： C07D401/06 ,  C07D401/14

    摘要： To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

    摘要翻译： 为了提供可用于预防或治疗抑郁症，焦虑症（例如广泛性焦虑症，创伤后应激障碍，恐慌症，强迫症或社交焦虑症）的新化合物，其药学上可接受的盐或水合物，注意力不足 精神分裂症，情绪障碍，压力，睡眠障碍，发作，记忆障碍，认知障碍，痴呆，遗忘症，deli妄症，肥胖症，进食障碍，食欲不振，食欲过盛，贪食症，恐惧症，糖尿病，心血管疾病 基于黑色素浓集激素受体（MCH受体）拮抗作用的疾病，高血压，血脂异常，心肌梗塞，运动障碍（如帕金森病，癫痫，惊厥或震颤），药物滥用，药物成瘾或性功能障碍。 溶液由式（I）表示的化合物，其药学上可接受的盐或水合物。

    MACROLIDE DERIVATIVE
    4.
    发明公开
    MACROLIDE DERIVATIVE 审中-公开
    MACROLIDE衍生物

    公开(公告)号：EP2077271A1

    公开(公告)日：2009-07-08

    申请号：EP07742762.3

    申请日：2007-05-01

    申请人： TAISHO PHARMACEUTICAL CO., LTD

    发明人： KASHIMURA, Masato ,  KAWAMURA, Madoka ,  ASAKA, Toshifumi ,  TAKAYAMA, Kiyoshi ,  OGITA, Haruhisa

    IPC分类号： C07H17/08 ,  A61K31/7048 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07H17/08 ,  A61K31/7048 ,  A61K31/7052 ,  C07H17/00

    摘要： Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a percutaneous coronary transluminal angioplasty, vascular atherosclerosis, hemorrhagic apoplexy, acute myocardial infarction, chronic heart failure, aneurysm, lung cancer metastasis, adult respiratory distress syndrome, asthma, interstitial pulmonary fibrosis, chronic rhinosinusitis, bronchitis or chronic obstructive pulmonary disease (COPD).

    摘要翻译： 由式（I）和式（IV）表示的化合物具有MMP-9产生的抑制活性，因此可用作副作用小于传统MMP酶活性抑制剂的药物，作为致癌的预防和治疗药物 血管生成，慢性风湿性关节炎，经皮冠状动脉腔内血管成形术后血管内膜增厚，血管动脉硬化，出血性中风，急性心肌梗塞，慢性心力衰竭，动脉瘤，肺癌转移，成人呼吸窘迫综合征，哮喘，间质性肺纤维化，慢性鼻窦炎， 支气管炎或慢性阻塞性肺病（COPD）。