-
1.发明公开
公开(公告)号：EP1424387A4
公开(公告)日：2005-10-12
申请号：EP02762780
申请日：2002-08-15
申请人： TAKARA BIO INC
发明人： SAGAWA HIROAKI , IDENO MITSUKO , KATO IKUNOSHIN
IPC分类号： A61K39/395 , A61P31/12 , A61P31/22 , A61P35/00 , A61P37/04 , C07K14/78 , C12N5/02 , C12N5/07 , C12N5/0783 , C12N15/09 , A61K35/14 , C12N5/06
CPC分类号： C12N5/0636 , A61K2039/515 , A61K2039/5158 , C12N2501/105 , C12N2501/12 , C12N2501/23 , C12N2501/515 , C12N2501/58 , C12N2501/599 , C12N2501/905
摘要： The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.
-
公开(公告)号：EP2028266A4
公开(公告)日：2010-08-11
申请号：EP07744884
申请日：2007-06-07
申请人： TAKARA BIO INC
发明人： MURAKI NOBUKO , IDENO MITSUKO , NAGAMINE KINUKO , TAKASHIMA FUYUKO , KOBAYASHI EIJI , KATO AKIKO , MARUI TAKAHIRO , SAGAWA HIROAKI , ENOKI TATSUJI , KATO IKUNOSHIN
IPC分类号： C12N5/00 , A61K35/12 , A61P37/02 , C07K14/78 , C07K19/00 , C12N5/0783 , C12N5/10 , C12N15/09
CPC分类号： C07K14/78 , A61K35/17 , A61K2039/5158 , C12N5/0636 , C12N2501/58 , C12N2533/52
摘要： A method for preparing lymphocytes characterized in that the method includes the step of culturing lymphocytes in the presence of a modified recombinant fibronectin fragment, in which a part of heparin binding domains of fibronectin overlaps. The method of the present invention gives a high cell proliferation rate, and the lymphocytes obtained by the present invention can be suitably used, for example, in adoptive immunotherapy, so that a significant contribution to the field of medicine is expected. In addition, according to the present invention, a novel modified recombinant fibronectin fragment is provided.
-
公开(公告)号：EP2476752A4
公开(公告)日：2013-04-03
申请号：EP10815445
申请日：2010-09-10
申请人： TAKARA BIO INC
发明人： IDENO MITSUKO , YABUUCHI MIE , JIN MEIKO , SATO MASAE , ASHIDA NAOKO , ENOKI TATSUJI
IPC分类号： C12N5/0783 , A61K35/14 , A61P31/06 , A61P31/10 , A61P31/18 , A61P35/02 , A61P37/04 , C12N5/02
CPC分类号： C12N5/0646 , A61K2035/124 , C12N2500/72 , C12N2501/2302 , C12N2501/24 , C12N2501/515 , C12N2502/1114
摘要： A process for producing a cell mass containing natural killer cells, characterized by involving a step of carrying out the expansion culture of a cell mass containing natural killer cells and/or cells capable of being differentiated into natural killer cells in the presence of a biological response modifier and cells that has been so treated as to lose a proliferation capability, and others.
-
公开(公告)号：EP1939278A4
公开(公告)日：2009-06-03
申请号：EP06810596
申请日：2006-09-27
申请人： TAKARA BIO INC
发明人： ENOKI TATSUJI , KATO AKIKO , MURAKI NOBUKO , IDENO MITSUKO , MARUI TAKAHIRO , SAGAWA HIROAKI , KATO IKUNOSHIN
IPC分类号： A61K35/14 , A61K35/76 , A61P1/16 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/16 , A61P35/00 , A61P37/04 , C07K14/78 , C12N5/0783 , C12N5/10 , C12N15/09
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/19 , A61K39/00 , A61K39/0011 , A61K2039/5158 , C12N15/86 , C12N2501/515 , C12N2501/58 , C12N2740/10043 , A61K2300/00
摘要： Disclosed is a method for production of a T cell population capable of expressing CD45RA and also expressing at least one substance selected from the group consisting of CD62L, CCR7, CD27 and CD28. The method comprises the step of cultivating a cell population containing T cells in the presence of a fibronectin, a fragment thereof or a mixture of the fibronectin and the fragment.
-
公开(公告)号：EP1666589A4
公开(公告)日：2006-10-04
申请号：EP04772194
申请日：2004-08-19
申请人： TAKARA BIO INC
发明人： IDENO MITSUKO , MURAKI NOBUKO , OGAWA KINUKO , KISHIMOTO MASAYUKI , ENOKI TATSUJI , SAGAWA HIROAKI , KATO IKUNOSHIN
CPC分类号： C12N5/0636 , C12N2501/58
摘要： It is intended to provide a process for producing cytotoxic lymphocytes characterized by involving the step wherein, by using a medium having a total concentration of serum and plasma in the medium of from 0% by volume and less than 5% by volume, at least one treatment selected from among the induction of cytotoxic lymphocytes, maintenance thereof and upscaled culture thereof is carried out in the presence of fibronectin, its fragment or a mixture of the same.
-
公开(公告)号：EP1496109A4
公开(公告)日：2006-07-19
申请号：EP03712887
申请日：2003-03-25
申请人： TAKARA BIO INC
发明人： SAGAWA HIROAKI , IDENO MITSUKO , KATO IKUNOSHIN
CPC分类号： C12N5/0638 , A61K2035/124 , C12N5/0636 , C12N2501/58 , C12N2510/00
摘要： The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.
-
公开(公告)号：EP1312670A4
公开(公告)日：2005-11-30
申请号：EP01956894
申请日：2001-08-15
申请人： TAKARA BIO INC
发明人： SAGAWA HIROAKI , IDENO MITSUKO , KATO IKUNOSHIN
IPC分类号： A61K35/14 , A61K35/16 , A61K39/00 , A61K39/145 , A61P37/04 , C12N5/0783 , C12N5/08 , A61K35/26
CPC分类号： C12N5/0636 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K2039/5158 , A61K2039/55583 , C12N2501/515 , C12N2501/90 , C12N2760/16134
摘要： A method of inducing, maintaining and extensively culturing CTLs (cytotoxic T cells), which sustain an antigen-specific cytotoxicity at a high level and are appropriately usable in adoptive immunotherapy, by using at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides and salts thereof as the active ingredient. Examples of the above-described compound include fucoidan, heparin, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, fucoidan degradation products, sulfated glucose, sulfated fucose and salts thereof.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.009 秒)
