公开(公告)号：EP1939278A4

公开(公告)日：2009-06-03

申请号：EP06810596

申请日：2006-09-27

申请人： TAKARA BIO INC

发明人： ENOKI TATSUJI ,  KATO AKIKO ,  MURAKI NOBUKO ,  IDENO MITSUKO ,  MARUI TAKAHIRO ,  SAGAWA HIROAKI ,  KATO IKUNOSHIN

IPC分类号： A61K35/14 ,  A61K35/76 ,  A61P1/16 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/16 ,  A61P35/00 ,  A61P37/04 ,  C07K14/78 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/09

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61K38/19 ,  A61K39/00 ,  A61K39/0011 ,  A61K2039/5158 ,  C12N15/86 ,  C12N2501/515 ,  C12N2501/58 ,  C12N2740/10043 ,  A61K2300/00

摘要： Disclosed is a method for production of a T cell population capable of expressing CD45RA and also expressing at least one substance selected from the group consisting of CD62L, CCR7, CD27 and CD28. The method comprises the step of cultivating a cell population containing T cells in the presence of a fibronectin, a fragment thereof or a mixture of the fibronectin and the fragment.

公开(公告)号：EP2028266A4

公开(公告)日：2010-08-11

申请号：EP07744884

申请日：2007-06-07

申请人： TAKARA BIO INC

发明人： MURAKI NOBUKO ,  IDENO MITSUKO ,  NAGAMINE KINUKO ,  TAKASHIMA FUYUKO ,  KOBAYASHI EIJI ,  KATO AKIKO ,  MARUI TAKAHIRO ,  SAGAWA HIROAKI ,  ENOKI TATSUJI ,  KATO IKUNOSHIN

IPC分类号： C12N5/00 ,  A61K35/12 ,  A61P37/02 ,  C07K14/78 ,  C07K19/00 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/09

CPC分类号： C07K14/78 ,  A61K35/17 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N2501/58 ,  C12N2533/52

摘要： A method for preparing lymphocytes characterized in that the method includes the step of culturing lymphocytes in the presence of a modified recombinant fibronectin fragment, in which a part of heparin binding domains of fibronectin overlaps. The method of the present invention gives a high cell proliferation rate, and the lymphocytes obtained by the present invention can be suitably used, for example, in adoptive immunotherapy, so that a significant contribution to the field of medicine is expected. In addition, according to the present invention, a novel modified recombinant fibronectin fragment is provided.

公开(公告)号：EP1916302A4

公开(公告)日：2009-10-21

申请号：EP06782667

申请日：2006-08-10

申请人： TAKARA BIO INC

发明人： MARUI TAKAHIRO ,  NAGAMINE KINUKO ,  MURAKI NOBUKO ,  KATO AKIKO ,  ENOKI TATSUJI ,  SAGAWA HIROAKI ,  KATO IKUNOSHIN

IPC分类号： C12N15/12 ,  A61K35/14 ,  A61P35/00 ,  C07K14/435 ,  C12N5/0783 ,  C12N5/10

CPC分类号： A61K35/17 ,  A61K35/26 ,  A61K2039/5154 ,  C07K14/78 ,  C12N5/0636 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/58 ,  C12N2531/00 ,  C12N2533/52 ,  G01N33/547