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4 条记录 (耗时 0.012 秒)

    REMEDIES
    1.
    发明公开
    REMEDIES 有权
    ARZNEIEN ZUR BEHANDLUNG VON NERVENERKRANKUNGEN

    公开(公告)号：EP1254658A1

    公开(公告)日：2002-11-06

    申请号：EP01946787.7

    申请日：2001-01-26

    申请人： TAKARA BIO INC.

    发明人： OHNOGI, Hiromu ,  SHIRAGA, Masahiro ,  KOBAYASHI, Eiji ,  LI, Tuo-Ping ,  DEGUCHI, Suzu ,  NISHIYAMA, Eiji ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： A61K31/12 ,  A61K31/216 ,  A61K31/352 ,  A61K31/7004 ,  A61P25/00 ,  A61P25/28 ,  A61P9/10 ,  A61P43/00 ,  A23L1/30 ,  C07C49/83 ,  C07C49/255 ,  C07C49/84 ,  C07C49/573 ,  C07C69/12

    CPC分类号： A61K31/7004 ,  A23L33/10 ,  A61K31/12 ,  A61K31/216 ,  A61K31/222 ,  A61K31/352

    摘要： The present invention provides a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production, each comprising as an effective ingredient a specified compound or a salt thereof having enhancing activity for nerve growth factor production; a method for enhancing nerve growth factor production, comprising administering to a mammal the above-mentioned compound or a salt thereof; and use of the above-mentioned compound or a salt thereof in the preparation of a therapeutic agent or prophylactic agent for a disease that requires enhancement of nerve growth factor production, an enhancer for nerve growth factor production, or a food, beverage or feed for enhancing nerve growth factor production. In addition, the present invention provides novel compounds having enhancing activity for nerve growth factor production.

    摘要翻译： 本发明提供了需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或用于增强神经生长因子产生的食品，饮料或饲料，其各自包含作为有效成分 具有增强神经生长因子生成活性的特定化合物或其盐; 一种用于增强神经生长因子产生的方法，包括向哺乳动物施用上述化合物或其盐; 以及上述化合物或其盐在制备需要增强神经生长因子产生的疾病的治疗剂或预防剂，用于神经生长因子产生的增强剂或食品，饮料或饲料中的用途 增强神经生长因子的产生。 此外，本发明提供了具有增强神经生长因子生产活性的新型化合物。

    REMEDIES
    3.
    发明公开
    REMEDIES 审中-公开
    医药有限公司

    公开(公告)号：EP1415657A1

    公开(公告)日：2004-05-06

    申请号：EP02746002.1

    申请日：2002-07-12

    申请人： TAKARA BIO INC.

    发明人： NISHIYAMA, Eiji ,  DEGUCHI, Suzu ,  OHNOGI, Hiromu ,  SUGIYAMA, Katsumi ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： A61K35/78 ,  A61K31/12 ,  A61P25/28 ,  A61P43/00 ,  A23L1/30 ,  A23L2/38 ,  A23K1/18

    CPC分类号： A61K36/185 ,  A23K20/10 ,  A23L33/105 ,  A61K31/12 ,  A61K36/232 ,  A61K2300/00

    摘要： According to the present invention, there is provided a medicament for oral administration or intravenous administration that is effective for a disease requiring enhancement of nerve growth factor production, comprising as an effective ingredient a pulverized product and/or extract obtained from Humulus lupulus and/or Angelica keiskei koidz., or xanthohumol and/or a pharmacologically acceptable salt thereof. 'The medicament is useful as a therapeutic agent or prophylactic agent for a disease requiring enhancement of nerve growth factor production, such as dementia or a nerve disorder.
    Also, according to the present invention, there are provided an enhancing agent for nerve growth factor production, and a food, beverage or feed for enhancing nerve growth factor production, each comprising the above effective ingredient. By taking the food or beverage as foodstuff on a daily basis, the symptoms of a disease requiring enhancement of nerve growth factor production can be ameliorated or the like. In addition, the feed is useful for maintaining homeostasis of a living body by its action of enhancing nerve growth factor production.
    Furthermore, these medicament and the like of the present invention are effective for improving or ameliorating learning and memorizing ability of an individual organism.

    摘要翻译： 用于口服或静脉内给药的药剂对于需要增强神经生长因子（NGF）生产的疾病是有效的，包括研磨材料和/或从啤酒花和/或当归keiskei获得的提取物。 还包括用于神经生长因子生产增强剂和食物，饮料和包含研磨材料的饲料和/或从啤酒花和/或当归keiskei或黄腐酚或其盐获得的提取物的独立权利要求。 活动：灵巧; 神经病理性。 在Wistar大鼠中，以10 mg / kg的xanthohumol的游泳到平台记忆测试在第2天至71.3秒之间降低了潜伏期，而对照组为133.4秒。 机制：NGF激动剂。