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    METHOD OF EXTENSIVE CULTURE OF ANTIGEN-SPECIFIC CYTOTOXIC T CELLS
    3.
    发明公开
    METHOD OF EXTENSIVE CULTURE OF ANTIGEN-SPECIFIC CYTOTOXIC T CELLS 审中-公开
    方法ZUR EXTENSIVEN KULTUR VON ANTIGEN-SPEZIFISCHEN CYTOTOXISCHEN T-ZELLEN

    公开(公告)号：EP1312670A1

    公开(公告)日：2003-05-21

    申请号：EP01956894.8

    申请日：2001-08-15

    申请人： TAKARA BIO INC.

    发明人： SAGAWA, Hiroaki ,  IDENO, Mitsuko ,  KATO, Ikunoshin

    IPC分类号： C12N5/08 ,  A61K35/26 ,  A61P37/04

    CPC分类号： C12N5/0636 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5158 ,  A61K2039/55583 ,  C12N2501/515 ,  C12N2501/90 ,  C12N2760/16134

    摘要： The present invention provides methods for inducing, maintaining and expanding CTL (cytotoxic T cell) having an antigen-specific cytotoxic activity at a high level, which is useful in the adoptive immunotherapy, by using as an effective ingredient at least one compound selected from the group consisting of acidic polysaccharides, acidic oligosaccharides, acidic monosaccharides, and salts thereof. The above-mentioned compounds include fucoidans, heparins, alginic acid, chondroitin sulfate A, chondroitin sulfate B, pectic acid, hyaluronic acid, degradation products of fucoidans, sulfated glucose, sulfated fucose and salts thereof.

    摘要翻译： 本发明提供了用于诱导，维持和扩增具有高水平的抗原特异性细胞毒性活性的CTL（细胞毒性T细胞）的方法，其可用于过继性免疫治疗，通过使用至少一种选自以下的化合物作为有效成分： 由酸性多糖，酸性寡糖，酸性单糖及其盐组成的组。 上述化合物包括岩藻多糖，肝素，海藻酸，硫酸软骨素A，硫酸软骨素B，果胶酸，透明质酸，岩藻多糖的降解产物，硫酸化葡萄糖，硫酸岩藻糖及其盐。

    PROCESS FOR PRODUCING CYTOTOXIC LYMPHOCYTES
    4.
    发明公开
    PROCESS FOR PRODUCING CYTOTOXIC LYMPHOCYTES 有权
    生产细胞毒性淋巴细胞的方法

    公开(公告)号：EP1666589A1

    公开(公告)日：2006-06-07

    申请号：EP04772194.9

    申请日：2004-08-19

    申请人： TAKARA BIO INC.

    发明人： IDENO, Mitsuko ,  MURAKI, Nobuko ,  OGAWA, Kinuko ,  KISHIMOTO, Masayuki ,  ENOKI, Tatsuji ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C12N15/09 ,  C07K14/47 ,  C12N5/08 ,  A61K35/26 ,  A61P35/00 ,  A61P37/04

    CPC分类号： C12N5/0636 ,  C12N2501/58

    摘要： The present invention provides a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one step selected from induction, maintenance and expansion of a cytotoxic lymphocyte using a medium containing serum and plasma at a total concentration of 0% by volume or more and less than 5% by volume, in the presence of fibronectin, a fragment thereof or a mixture thereof.

    摘要翻译： 本发明提供了一种制备细胞毒性淋巴细胞的方法，其特征在于该方法包括使用含有总浓度为0的血清和血浆的培养基进行选自诱导，维持和扩增细胞毒性淋巴细胞的至少一个步骤的步骤 在纤连蛋白，其片段或其混合物存在下，按体积％或更多并且按体积计小于5％。

    METHOD OF EXTENDED CULTURE FOR ANTIGEN-SPECIFIC CYTOTOXIC T LYMPHOCYTES
    5.
    发明公开
    METHOD OF EXTENDED CULTURE FOR ANTIGEN-SPECIFIC CYTOTOXIC T LYMPHOCYTES 有权
    延胡索酮抗生素抗生素ZYTOTOXISCHE T-LYMPHOZYTEN

    公开(公告)号：EP1424387A1

    公开(公告)日：2004-06-02

    申请号：EP02762780.1

    申请日：2002-08-15

    申请人： TAKARA BIO INC.

    发明人： SAGAWA, Hiroaki ,  IDENO, Mitsuko ,  KATO, Ikunoshin

    IPC分类号： C12N5/02 ,  C12N5/06 ,  A61K35/14 ,  A61P35/00

    CPC分类号： C12N5/0636 ,  A61K2039/515 ,  A61K2039/5158 ,  C12N2501/105 ,  C12N2501/12 ,  C12N2501/23 ,  C12N2501/515 ,  C12N2501/58 ,  C12N2501/599 ,  C12N2501/905

    摘要： The present invention is a method for inducing cytotoxic T cell having an antigen-specific cytotoxic activity, a method for maintaining the cell, a method for continuously culturing the cell or a method for expanding the cell, comprising the step of culturing a cytotoxic T cell in the presence of at least one substance selected from the group consisting of (A) a substance having a binding activity to CD44; (B) a substance capable of regulating a signal emitted by binding a CD44 ligand to CD44; (C) a substance capable of inhibiting binding of a growth factor to a growth factor receptor; (D) a substance capable of regulating a signal emitted by binding of a growth factor to a growth factor receptor; and (E) fibronectin, a fragment thereof or a mixture thereof.

    摘要翻译： 本发明是诱导具有抗原特异性细胞毒活性的细胞毒性T细胞的方法，用于维持细胞的方法，连续培养细胞的方法或扩增细胞的方法，包括培养细胞毒性T细胞的步骤 在至少一种选自（A）与CD44具有结合活性的物质的物质的存在下， （B）能够调节通过将CD44配体结合到CD44而发射的信号的物质; （C）能够抑制生长因子与生长因子受体结合的物质; （D）能够调节由生长因子与生长因子受体结合而发出的信号的物质; 和（E）纤连蛋白，其片段或其混合物。