-
公开(公告)号：EP1666589B1
公开(公告)日：2010-02-17
申请号：EP04772194.9
申请日：2004-08-19
申请人： TAKARA BIO INC.
发明人： IDENO, Mitsuko , MURAKI, Nobuko , OGAWA, Kinuko , KISHIMOTO, Masayuki , ENOKI, Tatsuji , SAGAWA, Hiroaki , KATO, Ikunoshin
CPC分类号： C12N5/0636 , C12N2501/58
-
2.发明公开METHOD OF STABILIZING REAGENT FOR AMPLIFYING OR DETECTING NUCLEIC ACID AND STORAGE METHOD 审中-公开方法用于稳定试剂扩增或用于核酸和储存过程中的检测
公开(公告)号：EP1396538A1
公开(公告)日：2004-03-10
申请号：EP02736063.5
申请日：2002-06-12
申请人： TAKARA BIO INC.
发明人： SAGAWA, Hiroaki , UEMORI, Takashi , MUKAI, Hiroyuki , YAMAMOTO, Junko , TOMONO, Jun; , KOBAYASHI, Eiji , ENOKI, Tatsuji , ASADA, Kiyozo , KATO, Ikunoshin
CPC分类号： C12Q1/6848 , C12Q2521/327 , C12Q2525/121 , C12Q2527/137
摘要： A method of stabilizing a reaction reagent for highly sensitively and specifically amplifying a target nucleic acid in a sample with the use of a chimeric oligonucleotide primer and a method of storing the same over a long time; and a method of highly sensitively detecting a pathogenic microorganism and a virus.
-
3.发明公开
公开(公告)号：EP1329516A1
公开(公告)日：2003-07-23
申请号：EP01974664.3
申请日：2001-10-03
申请人： TAKARA BIO INC.
发明人： ENOKI, Tatsuji , YAMASHITA, Shusaku , ROKUSHIMA, Masatomo , MINENO, Junichi , SAGAWA, Hiroaki , KATO, Ikunoshin
IPC分类号： C12Q1/68 , C12N15/09 , C12M1/00 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , A61K31/351 , A61K45/00
CPC分类号： G01N33/5088 , G01N2500/00
摘要： The present invention provides a method of screening a biologically active substance or a candidate substance for a biologically active substance, possessing an activity for controlling gene expression to the same extent to that of DGE; a gene controlling agent which is effective for maintaining homeostasis in a living body, for instance, purposed for mitigation or prevention of stress; and a method of controlling a gene.
摘要翻译： 本发明提供筛选生物活性物质或生物活性物质候选物质的方法，其具有与DGE相同程度的控制基因表达的活性; 用于维持活体内的体内平衡有效的基因控制剂，例如减轻或预防应激的基因控制剂; 和控制基因的方法。
-
4.发明公开AGENTS CORRECTING GENE EXPRESSION REGULATORY ERROR 审中-公开MITTEL ZUR KORREKTOR VON FEHLERN IN DER REGELUNG DER GEN-EXPRESSION
公开(公告)号：EP1254902A1
公开(公告)日：2002-11-06
申请号：EP01900659.2
申请日：2001-01-11
申请人： TAKARA BIO INC.
IPC分类号： C07D309/32 , C07D493/08 , A61K31/351 , A61K31/357 , A61P43/00 , A61P1/16 , A61P29/00
CPC分类号： A61K31/7004 , A61K31/35 , A61K31/351 , A61K31/7048 , C07D309/32 , C07D493/08
摘要： The present invention provides a suppressor for unbalance of gene expressions, characterized in that the suppressor comprises, as an effective ingredient, a specified compound; a therapeutic agent or prophylactic agent for a disease that requires modulating unbalance of expressions of a specified gene; and a method for modulating unbalance of gene expressions, characterized by administering to a mammal the above-mentioned compound.
摘要翻译： 本发明提供了基因表达不平衡的抑制剂，其特征在于抑制剂作为有效成分包含指定的化合物; 用于需要调节指定基因的表达不平衡的疾病的治疗剂或预防剂; 以及调节基因表达不平衡的方法，其特征在于向哺乳动物施用上述化合物。
-
公开(公告)号：EP3960755A1
公开(公告)日：2022-03-02
申请号：EP20795029.6
申请日：2020-04-23
申请人： Takara Bio Inc.
摘要： The present invention provides a nucleic acid which encodes an adeno-associated virus (AAV) capsid protein mutant that contains a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62 or a peptide comprising an amino acid sequence produced by substituting, deleting, inserting and/or adding one or several amino acid residues in an amino acid sequence selected from the group consisting of SEQ ID Nos. 15 to 62; DNA comprising the nucleic acid; a cell harboring the DNA; and a method for producing the cell.
-
-
公开(公告)号：EP2871239B1
公开(公告)日：2018-08-29
申请号：EP13813664.3
申请日：2013-06-26
申请人： Takara Bio Inc.
IPC分类号： C12N15/113 , C12N5/10 , C12N15/864 , C12N7/00 , C12N15/09
CPC分类号： C12N15/86 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/111 , C12N15/64 , C12N2310/141 , C12N2330/51 , C12N2501/65 , C12N2750/14143 , C12N2750/14151 , C12P19/34
摘要： According to the present invention, an AAV vector having a higher titer compared with those of conventional ones can be produced using a cell into which a nucleic acid capable of expressing miRNA is introduced artificially. An AAV vector produced using the cell and a composition containing the viral vector as an active ingredient are very useful as gene transfer means in the studies or clinical practice of gene therapies.
-
公开(公告)号：EP3020808A1
公开(公告)日：2016-05-18
申请号：EP14823074.1
申请日：2014-07-10
申请人： Takara Bio Inc.
发明人： SAKAMOTO, Shuhei , KAWANO, Yasuhiro , DODO, Katsuyuki , ENOKI, Tatsuji , YOSHIOKA, Hirofumi , TAKAKURA, Hikaru , MINENO, Junichi
CPC分类号： C12N7/00 , C12N2750/14151 , C12N15/86 , C12N2750/14143 , C12N2750/14043 , C12N2750/14122 , C12N2750/14142 , C12N7/02 , C12N2750/14141 , C12N2750/14351 , C12N2800/50 , C12N15/8673 , C12N2750/14352 , C12N2750/14152
摘要： The present invention provides a method for efficiently manufacturing a non-enveloped virus with high purity without laborious operation by cultivating cells having the ability to produce a non-enveloped virus and bringing the cells and an acidic solution into contact with each other. A non-enveloped virus vector manufactured by the method of the present invention and a composition having the non-enveloped viral vector as an active ingredient are very useful as gene transfer methods in the fields of basic research and clinical application gene therapy.
-
公开(公告)号：EP2940131A1
公开(公告)日：2015-11-04
申请号：EP13867056.7
申请日：2013-12-20
申请人： Takara Bio, Inc.
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143
摘要： The invention provides an AAV particle containing an adeno-associated viral (AAV) capsid protein having an amino acid sequence selected from the group consisting of SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 24, and SEQ ID NO: 30 of the sequence listing; a nucleic acid that encodes this capsid protein; DNA containing this nucleic acid; a cell containing this DNA; and a method for producing this cell.
摘要翻译： 本发明提供一种含有腺病毒（AAV）衣壳蛋白的AAV颗粒，其具有选自SEQ ID NO：15，SEQ ID NO：16，SEQ ID NO：24和SEQ ID NO的氨基酸序列 ：序列表中的30个; 编码该衣壳蛋白的核酸; 含有该核酸的DNA; 含有该DNA的细胞; 以及该细胞的制造方法。
-
公开(公告)号：EP3020808B1
公开(公告)日：2019-09-11
申请号：EP14823074.1
申请日：2014-07-10
申请人： Takara Bio Inc.
-
-
-
-
-
-
-
-
-
搜索结果
36 条记录 (耗时 0.022 秒)
