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公开(公告)号：EP0508417A3
公开(公告)日：1993-05-12
申请号：EP92106093.5
申请日：1992-04-09
IPC分类号： C12P21/08 , C12N15/12 , C07K13/00 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A61K38/00 , C07K14/47 , C07K14/705
摘要： The present invention relates to a monclonal antibody capable of suppressing the motility of cancer cells, a polypeptide recognizable by said anti-cancer antibody and its fragment peptides which is capable of suppressing the motility of cancer cells. The present invention also relates to a production and a use for preventing the metastasis of cancer thereof.
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公开(公告)号：EP0508417B1
公开(公告)日：1999-07-14
申请号：EP92106093.5
申请日：1992-04-09
IPC分类号： C12P21/08 , C12N15/12 , C07K14/435 , A61K39/395 , A61K38/17 , C07K16/30
CPC分类号： C07K16/30 , A61K38/00 , C07K14/47 , C07K14/705
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3.发明公开Monoclonal antibody, polypeptides and production thereof 失效MonokeparerAntikörper，Polypeptide und deren Herstellung。
公开(公告)号：EP0508417A2
公开(公告)日：1992-10-14
申请号：EP92106093.5
申请日：1992-04-09
IPC分类号： C12P21/08 , C12N15/12 , C07K13/00 , A61K39/395 , A61K37/02
CPC分类号： C07K16/30 , A61K38/00 , C07K14/47 , C07K14/705
摘要： The present invention relates to a monclonal antibody capable of suppressing the motility of cancer cells, a polypeptide recognizable by said anti-cancer antibody and its fragment peptides which is capable of suppressing the motility of cancer cells.
The present invention also relates to a production and a use for preventing the metastasis of cancer thereof.摘要翻译： 本发明涉及能够抑制癌细胞活力的单克隆抗体，能够抑制癌细胞活力的抗癌抗体所识别的多肽及其片段肽。 本发明还涉及用于预防癌症转移的生产和用途。
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4.发明公开Hepatitis B virus surface antigen and production thereof 失效乙型肝炎病毒Oberflächenantigen和dessen Herstellung。
公开(公告)号：EP0171908A2
公开(公告)日：1986-02-19
申请号：EP85304735.5
申请日：1985-07-03
CPC分类号： C12N15/81 , A61K38/00 , C07K14/005 , C12N15/78 , C12N2730/10122
摘要： Hepatitis B virus surface antigen P31 can be produced by cultivating a transformant carrying a recombinant DNA wherein a DNA coding for hepatitis B virus surface antigen P31 is inserted into the 3' end of a promoter region.
摘要翻译： 乙型肝炎病毒表面抗原P31可以通过培养携带重组DNA的转化体来制备，其中将编码乙型肝炎病毒表面抗原P31的DNA插入到启动子区的3分钟末端。
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5.发明公开Highly purified fused protein comprising human IgE Fc fragment and production thereof 失效高纯度融合蛋白，包含人造丝片段及其生产
公开(公告)号：EP0269455A3
公开(公告)日：1989-09-06
申请号：EP87310475.6
申请日：1987-11-27
发明人： Ikeyama, Shuichi , Nishimura, Osamu
CPC分类号： C07K16/00 , C07K2319/02 , C07K2319/30
摘要： A highly purified fused protein which comprises a first protein having the amino acid sequence:
Ala-Pro-Thr-Ser-Ser-Ser-Thr-Lys-Lys-Thr-Gln-Arg-Asn-Ser-Met-Leu and a human IgE Fc fragment joined to the C-terminus of the first protein, and a production method thereof comprising the purifying procedure comprising immunoaffinity chromatography. The fused protein is useful for allergy medicine.-
6.发明授权Antineoplastic pharmaceutical composition containing a fumagillol derivative and a platinum complex 失效包括烟霉醇衍生物和铂络合物抗肿瘤的药物组合物
公开(公告)号：EP0658342B1
公开(公告)日：1999-03-17
申请号：EP94114999.9
申请日：1994-09-23
IPC分类号： A61K31/335 , A61K47/40 , A61K31/28
CPC分类号： A61K31/335 , A61K31/28 , A61K2300/00
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7.发明公开Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation 失效3（2H） - 哒嗪酮衍生物和Herstellung。
公开(公告)号：EP0665223A1
公开(公告)日：1995-08-02
申请号：EP95101077.6
申请日：1995-01-26
发明人： Marui, Shogo , Aso, Kazuyoshi , Yamaoka, Masuo , Ikeyama, Shuichi
IPC分类号： C07D237/16 , C07D237/18 , A61K31/50
CPC分类号： C07D401/12 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2063 , C07D237/16 , C07D237/18 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Anti-tomor agents comprising novel 3(2H)-pyridazinone derivatives or salts thereof and methods of producing the same are disclosed. Also disclosed is a method for treating or preventing tumors by administering to a mammal a therapeutically effective amount of 4,5-di substituted 3(2H)-pyridazinones and salts thereof.
摘要翻译： 公开了包含新型3（2H） - 哒嗪酮衍生物或其盐的抗代谢剂及其制备方法。 还公开了通过向哺乳动物施用治疗有效量的4,5-二取代的3（2H） - 哒嗪酮及其盐来治疗或预防肿瘤的方法。
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公开(公告)号：EP0401941A3
公开(公告)日：1991-04-17
申请号：EP90202097.3
申请日：1985-07-03
CPC分类号： C12N15/81 , A61K38/00 , C07K14/005 , C12N15/78 , C12N2730/10122
摘要： The invention relates to a method for producing hepatitis B virus surface antigen P31 containing 55 amino acid residues of the pre-S region, which comprises (a) cultivating a transformant which carries a recombinant DNA in which a DNA coding for hepatitis B virus surface antigen P31 containing 55 amino acid residues of the pre-S region is inserted into the 3′ end of a promoter region, (b) accumulating the hepatitis B virus surface antigen P31 in the culture, (c) collecting the P31-containing solution from the culture, (d) subjecting the P31-containing solution to a column containing polymerised human serum albumin as a ligand, (e) eluting the hepatitis B virus surface antigen P31 from the column with a buffer containing a surfactant or a protein denaturing agent, and (f) subjecting the eluate to chromatographic treatment using a hydrophobic column or hydrophobic chromatography.
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9.发明公开Antineoplastic pharmaceutical composition containing a fumagillol derivative 失效Antineoplastische pharmazeutische Zusammensetzung mit einem Fumagillolderivat。
公开(公告)号：EP0658342A1
公开(公告)日：1995-06-21
申请号：EP94114999.9
申请日：1994-09-23
IPC分类号： A61K31/335 , A61K47/40 , A61K31/28
CPC分类号： A61K31/335 , A61K31/28 , A61K2300/00
摘要： There is provided an antineoplastic pharmaceutical composition for plural administrations which comprises a fumagillol derivative having angiogenesis inhibitory activity or a salt thereof in combination with a platinum complex having cytocidal activity, and a pharmaceutically acceptable carrier or excipient. The combination of the drugs produces excellent antineoplastic activity and reduces side effects.
摘要翻译： 提供了一种用于多次施用的抗肿瘤药物组合物，其包含具有血管生成抑制活性的烟曲霉醇衍生物或其盐与具有杀细菌活性的铂络合物组合，和药学上可接受的载体或赋形剂。 药物的组合产生优异的抗肿瘤活性并减少副作用。
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10.发明公开Hepatitis B virus surface antigen and production thereof 失效乙型肝炎病毒Oberflächen-Antigen和seine Herstellung。
公开(公告)号：EP0401941A2
公开(公告)日：1990-12-12
申请号：EP90202097.3
申请日：1985-07-03
CPC分类号： C12N15/81 , A61K38/00 , C07K14/005 , C12N15/78 , C12N2730/10122
摘要： The invention relates to a method for producing hepatitis B virus surface antigen P31 containing 55 amino acid residues of the pre-S region, which comprises (a) cultivating a transformant which carries a recombinant DNA in which a DNA coding for hepatitis B virus surface antigen P31 containing 55 amino acid residues of the pre-S region is inserted into the 3′ end of a promoter region, (b) accumulating the hepatitis B virus surface antigen P31 in the culture, (c) collecting the P31-containing solution from the culture, (d) subjecting the P31-containing solution to a column containing polymerised human serum albumin as a ligand, (e) eluting the hepatitis B virus surface antigen P31 from the column with a buffer containing a surfactant or a protein denaturing agent, and (f) subjecting the eluate to chromatographic treatment using a hydrophobic column or hydrophobic chromatography.
摘要翻译： 本发明涉及含有前S区55个氨基酸残基的乙型肝炎病毒表面抗原P31的生产方法，该方法包括：（a）培养携带重组DNA的转化体，其中编码乙型肝炎病毒表面抗原的DNA 将含有前S区的55个氨基酸残基的P31插入启动子区的3分钟末端，（b）在培养物中积聚乙型肝炎病毒表面抗原P31，（c）从含有P31的溶液中收集含有P31的溶液 培养，（d）使含P31的溶液经受含有聚合的人血清白蛋白的柱作为配体，（e）用含有表面活性剂或蛋白质变性剂的缓冲液从所述柱洗脱乙型肝炎病毒表面抗原P31，以及 （f）使用疏水柱或疏水层析对洗脱液进行色谱处理。
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