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公开(公告)号：EP0991619B1
公开(公告)日：2003-09-10
申请号：EP98931521.3
申请日：1998-06-23
发明人： LOBL, Thomas J., Coulter Pharmaceutical , RISHTON, Gil , TEEGARDEN, Bradley , POLINSKY, Alex , YAMAGISHI, Masafumi , TANIS, Steven, P. , FISHER, Jed, F. , THOMAS, Edward, W. , CHRUSCIEL, Robert, A.
IPC分类号： C07C233/63 , C07C233/87 , A61K31/16
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to formula (I), which are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号：EP1089989A1
公开(公告)日：2001-04-11
申请号：EP99930614.5
申请日：1999-06-23
发明人： BLINN, James, R. , CHRUSCIEL, Robert, A. , FISHER, Jed, F. , TANIS, Steven, P. , THOMAS, Edward, William , LOBL, Thomas, J. , TEEGARDEN, Bradley, R.
IPC分类号： C07D277/00
CPC分类号： C07D207/26 , C07D205/04 , C07D207/16 , C07D207/28 , C07D211/60 , C07D211/62 , C07D223/06 , C07D263/06 , C07D277/06 , C07D277/60 , C07D279/12 , C07D281/06 , C07D401/06 , C07D405/04 , C07D405/06 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D513/04 , C07D513/10 , C07K5/06139
摘要： The present invention relates to compound of formula (I), that are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which could be useful for the treatment of inflammatory diseases. Specifically, the molecules of the present invention can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human. This method may comprise administering to a mammal or a human patient an effective amount of the compound or composition as explained in the present specification.
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公开(公告)号：EP0991619A1
公开(公告)日：2000-04-12
申请号：EP98931521.3
申请日：1998-06-23
发明人： LOBL, Thomas J.-Coulter Pharmaceutical , RISHTON, Gil , TEEGARDEN, Bradley , POLINSKY, Alex , YAMAGISHI, Masafumi , TANIS, Steven, P. , FISHER, Jed, F. , THOMAS, Edward, W. , CHRUSCIEL, Robert, A.
IPC分类号： C07C233/63 , C07C233/87 , A61K31/16
CPC分类号： C07D213/81 , C07C229/46 , C07C233/60 , C07C233/63 , C07C233/83 , C07C233/87 , C07C235/40 , C07C235/64 , C07C235/84 , C07C237/22 , C07C237/40 , C07C237/42 , C07C255/29 , C07C255/46 , C07C259/08 , C07C271/22 , C07C271/28 , C07C275/26 , C07C275/42 , C07C311/21 , C07C311/64 , C07D207/16 , C07D209/20 , C07D213/64 , C07D213/82 , C07D217/26 , C07D233/64 , C07D295/185 , C07D295/192 , C07D307/68 , C07D333/24
摘要： The present invention relates to small molecules according to formula (I), which are potent inhibitors of α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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4.发明公开INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION 有权INHIBITOREN DER ALPHA-4 BETA-1 VERMITTELTENZELLADHÄSION
公开(公告)号：EP1144365A3
公开(公告)日：2003-07-09
申请号：EP99966584.7
申请日：1999-12-20
发明人： TEEGARDEN, Bradley, R. , JAYAKUMAR, Honnappa , MATSUKI, Kenji , CHRUSCIEL, Robert, A. , FISHER, Jed, F. , TANIS, Steven, P. , THOMAS, Edward, W. , BLINN, James, R.
IPC分类号： C07C235/00
CPC分类号： C07D213/64 , A61K38/00 , C07C235/20 , C07C235/74 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/24 , C07C237/42 , C07C255/31 , C07C275/26 , C07C275/42 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/14 , C07D237/14 , C07D295/215 , C07D307/24 , C07D307/71 , C07D317/58 , C07K5/0202 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0821
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公开(公告)号：EP1144365B1
公开(公告)日：2004-03-17
申请号：EP99966584.7
申请日：1999-12-20
发明人： TEEGARDEN, Bradley, R. , JAYAKUMAR, Honnappa , MATSUKI, Kenji , CHRUSCIEL, Robert, A. , FISHER, Jed, F. , TANIS, Steven, P. , THOMAS, Edward, W. , BLINN, James, R.
IPC分类号： C07C235/00
CPC分类号： C07D213/64 , A61K38/00 , C07C235/20 , C07C235/74 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/24 , C07C237/42 , C07C255/31 , C07C275/26 , C07C275/42 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/14 , C07D237/14 , C07D295/215 , C07D307/24 , C07D307/71 , C07D317/58 , C07K5/0202 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0821
摘要： The present invention relates to small molecules according to formula (I) which are potent inhibitors of a α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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公开(公告)号：EP1144365A2
公开(公告)日：2001-10-17
申请号：EP99966584.7
申请日：1999-12-20
发明人： TEEGARDEN, Bradley, R. , JAYAKUMAR, Honnappa , MATSUKI, Kenji , CHRUSCIEL, Robert, A. , FISHER, Jed, F. , TANIS, Steven, P. , THOMAS, Edward, W. , BLINN, James, R.
IPC分类号： C07C235/00
CPC分类号： C07D213/64 , A61K38/00 , C07C235/20 , C07C235/74 , C07C235/78 , C07C235/82 , C07C235/84 , C07C237/24 , C07C237/42 , C07C255/31 , C07C275/26 , C07C275/42 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07D207/16 , C07D211/60 , C07D211/62 , C07D213/81 , C07D213/82 , C07D215/48 , C07D231/14 , C07D237/14 , C07D295/215 , C07D307/24 , C07D307/71 , C07D317/58 , C07K5/0202 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0821
摘要： The present invention relates to small molecules according to formula (I) which are potent inhibitors of a α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
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7.发明授权SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES 失效用于治疗HIV和其他逆转录病毒疾病特窗酸衍生物
公开(公告)号：EP0817786B1
公开(公告)日：2003-02-19
申请号：EP96911227.5
申请日：1996-03-07
发明人： CHRUSCIEL, Robert, A. , MAGGIORA, Linda, Louise , THAISRIVONGS, Suvit , TUSTIN, James, Michael , SMITH, Clark, William , TOMMASI, Ruben , ARISTOFF, Paul, Adrian , SKULNICK, Harvey, Irving , HOWE, W., Jeffrey
IPC分类号： C07D491/107 , C07D307/40 , A61K31/365 , A61K31/445 , A61K31/495 , C07D491/02
CPC分类号： C07D405/12 , C07D307/60 , C07D307/94 , C07D491/10
摘要： This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
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8.发明公开SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES 失效用于治疗HIV和其他逆转录病毒疾病特窗酸衍生物
公开(公告)号：EP0817786A1
公开(公告)日：1998-01-14
申请号：EP96911227.0
申请日：1996-03-07
发明人： CHRUSCIEL, Robert, A. , MAGGIORA, Linda, Louise , THAISRIVONGS, Suvit , TUSTIN, James, Michael , SMITH, Clark, William , TOMMASI, Ruben , ARISTOFF, Paul, Adrian , SKULNICK, Harvey, Irving , HOWE, W., Jeffrey
CPC分类号： C07D405/12 , C07D307/60 , C07D307/94 , C07D491/10
摘要： This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
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