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公开(公告)号：EP0758327B1
公开(公告)日：2003-04-09
申请号：EP95918864.0
申请日：1995-05-04
发明人： ROMINES, Karen, Rene , BUNDY, Gordon, L. , SCHWARTZ, Theresa, M. , TOMMASI, Ruben, A. , STROHBACH, Joseph, Walter , TURNER, Steven, Ronald , THAISRIVONGS, Suvit , ARISTOFF, Paul, Adrian , JOHNSON, Paul, D. , SKULNICK, Harvey, Irving , SKALETZKI, Louis, L. , ANDERSON, David, John , MORRIS, Joel , GAMMILL, Ronald, B. , LUKE, George, P.
IPC分类号： C07D309/32 , C07D309/38 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/365 , A61K31/44 , A61K31/47 , A61K31/415 , A61K31/505 , A61K31/54
CPC分类号： C07D405/12 , C07D309/32 , C07D309/38 , C07D311/02 , C07D311/74 , C07D405/14
摘要： The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R10 and R20 taken together are formulae (III) and (IV).
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2.发明授权4-HYDROXY-BENZOPYRAN-2-ONES AND 4-HYDROXY-CYCLOALKYL B]PYRAN-2-ONES USEFUL TO TREAT RETROVIRAL INFECTIONS 失效4羟基苯并吡喃-2-酮和4-羟基 - 环烷基（B） - PYRAN - 2-ONE用于病毒感染复古处理
公开(公告)号：EP0682663B1
公开(公告)日：2001-04-18
申请号：EP94908648.2
申请日：1994-02-03
发明人： ANDERSON, David John , BANITT, Lee S. , TOMICH, Paul Kosta , BOHANON, Michael John , TURNER, Steven Ronald , STROHBACH, Joseph Walter , THAISRIVONGS, Suvit , YANG, Chih-Ping , THOMAS, Richard, Charles , ROMINES, Karen, Rene , ARISTOFF, Paul, Adrian , SKULNICK, Harvey, Irving , JOHNSON, Paul, D. , GAMMILL, Ronald, B. , ZHANG, Qingwei , BUNDY, Gordon, L.
IPC分类号： C07D311/46 , C07D311/54 , C07D311/92 , C07D311/74 , C07D311/94 , C07D407/06 , C07D409/06 , A61K31/37
CPC分类号： C07D405/04 , C07D311/56 , C07D311/74 , C07D311/94 , C07D405/12 , C07D407/06 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/582
摘要： The present invention relates to compounds of formula (I) which are 4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl[b]pyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. In formula (I) R10 and R20 taken together are formula (II) or formula (III).
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3.发明公开SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES 失效用于治疗HIV和其他逆转录病毒疾病特窗酸衍生物
公开(公告)号：EP0817786A1
公开(公告)日：1998-01-14
申请号：EP96911227.0
申请日：1996-03-07
发明人： CHRUSCIEL, Robert, A. , MAGGIORA, Linda, Louise , THAISRIVONGS, Suvit , TUSTIN, James, Michael , SMITH, Clark, William , TOMMASI, Ruben , ARISTOFF, Paul, Adrian , SKULNICK, Harvey, Irving , HOWE, W., Jeffrey
CPC分类号： C07D405/12 , C07D307/60 , C07D307/94 , C07D491/10
摘要： This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
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公开(公告)号：EP0758327A1
公开(公告)日：1997-02-19
申请号：EP95918864.0
申请日：1995-05-04
发明人： ROMINES, Karen, Rene , BUNDY, Gordon, L. , SCHWARTZ, Theresa, M. , TOMMASI, Ruben, A. , STROHBACH, Joseph, Walter , TURNER, Steven, Ronald , THAISRIVONGS, Suvit , ARISTOFF, Paul, Adrian , JOHNSON, Paul, D. , SKULNICK, Harvey, Irving , SKALETZKI, Louis, L. , ANDERSON, David, John , MORRIS, Joel , GAMMILL, Ronald, B. , LUKE, George, P.
IPC分类号： C07D , A61K31 , A61P31 , C07D309 , C07D311 , C07D401 , C07D403 , C07D405 , C07D407 , C07D409 , C07D417
CPC分类号： C07D405/12 , C07D309/32 , C07D309/38 , C07D311/02 , C07D311/74 , C07D405/14
摘要： The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R10 and R20 taken together are formulae (III) and (IV).
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5.发明授权SUBSTITUTED TETRONIC ACIDS USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES 失效用于治疗HIV和其他逆转录病毒疾病特窗酸衍生物
公开(公告)号：EP0817786B1
公开(公告)日：2003-02-19
申请号：EP96911227.5
申请日：1996-03-07
发明人： CHRUSCIEL, Robert, A. , MAGGIORA, Linda, Louise , THAISRIVONGS, Suvit , TUSTIN, James, Michael , SMITH, Clark, William , TOMMASI, Ruben , ARISTOFF, Paul, Adrian , SKULNICK, Harvey, Irving , HOWE, W., Jeffrey
IPC分类号： C07D491/107 , C07D307/40 , A61K31/365 , A61K31/445 , A61K31/495 , C07D491/02
CPC分类号： C07D405/12 , C07D307/60 , C07D307/94 , C07D491/10
摘要： This application discloses novel tetronic acids for the treatment of AIDS and other diseases caused by retroviruses.
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6.发明授权PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES 失效吡喃-2-酮和5,6-二氢-2-都非常有用艾滋病毒和其他TETROVIREN的治疗
公开(公告)号：EP0668860B1
公开(公告)日：2002-09-11
申请号：EP94900546.6
申请日：1993-11-09
发明人： THAISRIVONGS, Suvit , YANG, Chih-Ping , STROHBACH, Joseph, Walter , TURNER, Steven, Ronald , ROMERO, Donna, Lee , SKALETZKI, Louis, L, , ARISTOFF, Paul, Adrian , GAMMILL, Ronald, B, , JOHNSON, Paul, D. , SKULNICK, Harvey, Irving , PIPER, Richard, C, , TOMMASI, Ruben, A. , ZHANG, Qingwei
IPC分类号： C07D309/38 , C07D309/32 , A61K31/365
CPC分类号： C07D405/06 , C07D309/32 , C07D309/38 , C07D311/96 , C07D405/12 , C07D407/06 , C07D409/06 , C07D409/14 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12
摘要： The present invention relates to compounds of formula (I) which are pyran-2-ones and 5,6-dihydropyran-2-ones useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.
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