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    AIR-COOLING DROP PILL PRODUCTION LINE
    7.
    发明公开
    AIR-COOLING DROP PILL PRODUCTION LINE 审中-公开

    公开(公告)号：EP3020387A4

    公开(公告)日：2018-01-10

    申请号：EP14822215

    申请日：2014-07-11

    申请人： TASLY PHARMACEUTICAL GROUP CO

    发明人： YAN XIJUN ,  SUN XIAOBING ,  ZHENG YONGFENG ,  FAN LIJUN ,  FU YAN

    IPC分类号： A61J3/06 ,  A61K9/20 ,  A61K9/48 ,  A61K36/537 ,  A61P9/00 ,  A61P9/02 ,  A61P9/10 ,  B01J2/04 ,  B01J2/18 ,  B01J3/00 ,  B01J13/04

    CPC分类号： A61J3/005 ,  A61J3/06 ,  A61J2200/42 ,  A61J2200/44

    摘要： An air-cooling drop pill production line comprises a drop pill system, an air-cooling circulation system and a control system. The drop pill system comprises a molten material tank and a dripper. A vibration apparatus is arranged between the molten material tank and the dripper, and drives the dripper to vibrate up and down. A vibration shear force cuts liquor flowing out from the dripper into drops, and drop pills are formed after the drops fall into the air-cooling circulation system and are cooled. An online monitoring apparatus is arranged on the dripper, and comprises a pulse signal emission mechanism with an emission frequency which is the same as a vibration frequency of the vibration apparatus. The control system controls and regulates a dropping parameter according to a monitoring result of the online monitoring apparatus. The present invention combines vibration dropping, online monitoring and controlling, air cooling, and fluidized drying and coating together, which satisfies the requirement of high-speed dropping, micro pill preparation and improving a drug-loading capacity. Thus, the drug-loading capacity of drop pills can be multiply improved, the usage of auxiliary materials and the dosage can be greatly reduced, organic solvent residual can be completely avoided, and requirements of different processes including slow-release coating, film coating and sugar coating can be satisfied.

    SALVIA MILTIORRHIZA EXTRACT, MICROPELLET FORMULATION THEREOF, METHODS OF PREPARING SAME, AND USES THEREOF
    9.
    发明公开
    SALVIA MILTIORRHIZA EXTRACT, MICROPELLET FORMULATION THEREOF, METHODS OF PREPARING SAME, AND USES THEREOF 审中-公开
    丹参提取物，微球制剂其方法其生产及其用途

    公开(公告)号：EP3011965A4

    公开(公告)日：2017-02-22

    申请号：EP14813421

    申请日：2014-06-17

    申请人： TASLY PHARMACEUTICAL GROUP CO

    发明人： YAN XIJUN ,  ZHANG SHUNNAN ,  YE ZHENGLIANG ,  ZHOU LIHONG ,  DONG HAI'OU ,  ZHANG WENSHENG ,  ZHANG HONGBO ,  MA CHANGYU ,  ZHENG YONGFENG ,  FAN LIJUN

    IPC分类号： A61K36/537 ,  A61K9/16 ,  A61P9/14

    CPC分类号： A61K36/537 ,  A61K9/1664

    摘要： A salvia miltiorrhiza extract, a micropellet formulation thereof, method of preparing same, and uses thereof are disclosed. The salvia miltiorrhiza extract contains the following component weight ratio: salvia miltiorrhiza element : rosmarinic acid : lithospermic acid : salvianolic acid B : cryptotanshinone : tanshinone IIA : stachyose=(0.5-16) : (0.5-15) : (0.5-15) : (5-140) : (0.5-25) : (1-50) : (150-600). The salvia miltiorrhiza extract of the present invention also contains a liposoluble active ingredient and a water-soluble active ingredient of salvia miltiorrhiza. The invention has excellent stability, contains low amounts of solvent residue, improves microcirculation and reduces blood lipid levels.

    摘要翻译： 甲丹参提取物，微球制剂它们，制备相同的方法，及其用途游离缺失光盘。 丹参提取物包含以下组分重量比：丹参元件：迷迭香酸：紫草酸：酚酸B：隐：丹参酮IIA：水苏糖=（0.5-16）（0.5-15）（0.5-15）： （5-140）：（0.5-25）：（1-50）：（150-600）。 因此，本发明的丹参提取物含有脂溶性活性成分和丹参的水溶性活性成分。 本发明具有优异的稳定性，包含溶剂残留量低的量，提高微循环和降低血脂水平。