公开(公告)号：EP0180384A3

公开(公告)日：1987-09-30

申请号：EP85307513

申请日：1985-10-17

申请人： TECHNICON INSTRUMENTS CORPORATION (a New York corporation)

发明人： Cohen, Beri ,  Wong, Tak K. ,  Hargitay, Bartholomew

IPC分类号： G01N33/546 ,  G01N33/553

CPC分类号： B03C1/01 ,  C12N11/08 ,  C12N11/14 ,  G01N33/5434 ,  G01N33/545 ,  G01N2446/10 ,  G01N2446/20

摘要： A stable magnetically responsive, substantially remanence-free reagent carrier comprises an iron oxide colloidally dispersed in a smooth particulate polymeric matrix having preferentially a hydrated diameter of from about 0.5 to about 100 µm. The reagent carrier is prepared by a process which includes incorporating iron salts by passive transport into substantially spherical, water-swellable polymeric matrices, converting in situ the iron salts so-incorporated into their respective iron oxides. The carrier with a reagent attached thereto is useful inter alia in immunoassays.

公开(公告)号：EP0186352A3

公开(公告)日：1987-08-05

申请号：EP85308875

申请日：1985-12-05

申请人： TECHNICON INSTRUMENTS CORPORATION (a New York corporation)

发明人： Cohen, Beri

IPC分类号： A61K09/50

CPC分类号： A61K9/1277 ,  Y10S436/829 ,  Y10T428/2984

摘要： Lipid vesicles are formed by providing a lipidcoating on a deformable surface and fragmenting the lipid coating during hydration by deformation of the surface. The resulting fragments of the lipid coating are dispersed in the hydrating medium, so as to be subjected to multidirectional hydration, whereby formation of vesicles is accelerated. In a preferred embodiment, the surface is defined by a plurality of water-swellable particles formed of a polymeric material.