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    TRANSDERMAL PREPARATION
    1.
    发明公开
    TRANSDERMAL PREPARATION 审中-公开
    TRANSDERMALESPRÄPARAT

    公开(公告)号：EP3150205A1

    公开(公告)日：2017-04-05

    申请号：EP15800275.8

    申请日：2015-05-20

    申请人： Teikoku Seiyaku Co., Ltd.

    发明人： KAWAKAMI, Satoshi ,  SHIBATA, Taiki ,  SOGABE, Manabu

    IPC分类号： A61K31/404 ,  A61K9/70 ,  A61K31/18 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34 ,  A61P13/12 ,  A61P43/00

    CPC分类号： A61K31/18 ,  A61K9/70 ,  A61K9/7061 ,  A61K31/404 ,  A61K47/10 ,  A61K47/32 ,  A61K47/34

    摘要： Provided is a novel transdermal absorption preparation containing silodosin or tamsulosin, or salt thereof as an active ingredient, wherein the transdermal absorption preparation is capable of keeping a dissolved state for a long time, as well as has a high permeability to a skin, and can effectively and sustainably exert the transdermal absorbability. A transdermal absorption preparation containing the transdermal absorption preparation comprises an acrylic pressure-sensitive adhesive that comprises a copolymer of at least one (meth)acrylic acid monomer and at least one vinyl monomer and that contains a carboxyl group, and at least one transdermal absorption promoting agent selected from the group consisting of oleyl alcohol, lauryl alcohol, and lauromacrogol.

    摘要翻译： 本发明提供一种含有西洛多辛或坦索罗辛或其盐作为活性成分的新型透皮吸收制剂，其中经皮吸收制剂能够长期保持溶解状态，并且具有对皮肤的高渗透性，并且可以 有效和可持续地发挥经皮吸收能力。 含有透皮吸收制剂的透皮吸收制剂包括丙烯酸类压敏粘合剂，其包含至少一种（甲基）丙烯酸单体和至少一种乙烯基单体并且含有羧基的共聚物，以及至少一种透皮吸收促进剂 选自油醇，月桂醇和月桂醇的组合物。

    TOLTERODINE-CONTAINING ADHESIVE PATCH
    7.
    发明公开
    TOLTERODINE-CONTAINING ADHESIVE PATCH 审中-公开
    毒死蜱

    公开(公告)号：EP2799066A1

    公开(公告)日：2014-11-05

    申请号：EP12861215.7

    申请日：2012-12-25

    申请人： TEIKOKU SEIYAKU CO., LTD.

    发明人： SHIBATA, Taiki ,  MURATA, Kensuke ,  HATTORI, Kenichi ,  TANAKA, Shinji

    IPC分类号： A61K31/137 ,  A61K9/70 ,  A61K47/32

    CPC分类号： A61K31/137 ,  A61K9/7053 ,  A61K31/70 ,  A61K31/7076 ,  A61K31/7084

    摘要： The present invention provides a tolterodine-containing patch in which an adhesive layer is laminated on a backing, characterized in that the adhesive layer is obtainable by adding tolterodine to an adhesive base comprising a rubber adhesive, a tackifier resin, and a softener, wherein the tolterodine is present in the form of a free base in the adhesive base.

    摘要翻译： 本发明提供了含有托特罗定的贴剂，其中粘合剂层层压在背衬上，其特征在于，通过向包含橡胶粘合剂，增粘树脂和软化剂的粘合剂基底添加托特罗定可获得粘合剂层，其中 托特罗定以粘合剂基质中游离碱的形式存在。

    ANTI-INFLAMMATORY ANALGESIC ADHESIVE PATCH FOR EXTERNAL USE
    8.
    发明公开
    ANTI-INFLAMMATORY ANALGESIC ADHESIVE PATCH FOR EXTERNAL USE 有权
    ENTZÜNDUNGSHEMMENDESUND SCHMERZSTILLESES HEFTPFLASTER ZUR EXTERNEN ANWENDUNG

    公开(公告)号：EP2524692A1

    公开(公告)日：2012-11-21

    申请号：EP11731785.9

    申请日：2011-01-05

    申请人： Teikoku Seiyaku Co., Ltd. ,  Ibsa Institut Biochimique S.A.

    发明人： SHIBATA, Taiki ,  MABUCHI, Yuichiro ,  HATTORI, Kenichi ,  KAMAKURA, Takashi

    IPC分类号： A61K31/40 ,  A61K9/70 ,  A61K47/10 ,  A61K47/20 ,  A61K47/22 ,  A61K47/32

    CPC分类号： A61K31/40 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/196 ,  Y10T156/10 ,  A61K2300/00

    摘要： An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene·isoprene·styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.

    摘要翻译： 通过将粘合剂层层压在背衬上制备的含有双氯芬酸羟乙基吡咯烷的外部贴片，其中所述粘合剂层的特征在于包含5-50重量％的苯乙烯·异戊二烯·苯乙烯嵌段共聚物，20-50重量％的增粘树脂， 5-70重量％的软化剂和0.5-20重量％的一种或多种选自N-甲基-2-吡咯烷酮，丙二醇和二甲基亚砜作为必需成分的增溶剂，和0.5-20重量％ 双氯芬酸羟乙基吡咯烷作为活性成分。 该贴剂具有优异的透皮吸收，较少的皮肤刺激和优异的药物稳定性。