公开(公告)号：EP2224912A1

公开(公告)日：2010-09-08

申请号：EP08866209.3

申请日：2008-12-31

申请人： TEKMIRA Pharmaceuticals Corporation ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  Alnylam Pharmaceuticals

发明人： HOPE, Michael, J. ,  SEMPLE, Sean, C. ,  CHEN, Jianxin ,  MADDEN, Thomas, D. ,  MUI, Barbara ,  CULLIS, Pieter, R. ,  CIUFOLINI, Marco, A. ,  WONG, Kim, F. ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  SRINIVASULU, Masunu

IPC分类号： A61K9/127 ,  A61K31/7088

CPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K9/1275 ,  C07C215/10 ,  C07C217/08 ,  C07C217/28 ,  C07C219/08 ,  C07C229/12 ,  C07C271/12 ,  C07C323/25 ,  C07D317/28

摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

公开(公告)号：EP2224912B1

公开(公告)日：2016-05-11

申请号：EP08866209.3

申请日：2008-12-31

申请人： TEKMIRA Pharmaceuticals Corporation ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  Alnylam Pharmaceuticals

发明人： HOPE, Michael, J. ,  SEMPLE, Sean, C. ,  CHEN, Jianxin ,  MADDEN, Thomas, D. ,  MUI, Barbara ,  CULLIS, Pieter, R. ,  CIUFOLINI, Marco, A. ,  WONG, Kim, F. ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  SRINIVASULU, Masunu

IPC分类号： A61K9/127 ,  A61K31/7088 ,  C07D317/28 ,  C07C229/30

CPC分类号： A61K31/7088 ,  A61K9/127 ,  A61K9/1275 ,  C07C215/10 ,  C07C217/08 ,  C07C217/28 ,  C07C219/08 ,  C07C229/12 ,  C07C271/12 ,  C07C323/25 ,  C07D317/28