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公开(公告)号：EP2224912A1
公开(公告)日：2010-09-08
申请号：EP08866209.3
申请日：2008-12-31
申请人： TEKMIRA Pharmaceuticals Corporation , THE UNIVERSITY OF BRITISH COLUMBIA , Alnylam Pharmaceuticals
发明人： HOPE, Michael, J. , SEMPLE, Sean, C. , CHEN, Jianxin , MADDEN, Thomas, D. , MUI, Barbara , CULLIS, Pieter, R. , CIUFOLINI, Marco, A. , WONG, Kim, F. , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil, G. , SRINIVASULU, Masunu
IPC分类号： A61K9/127 , A61K31/7088
CPC分类号： A61K31/7088 , A61K9/127 , A61K9/1275 , C07C215/10 , C07C217/08 , C07C217/28 , C07C219/08 , C07C229/12 , C07C271/12 , C07C323/25 , C07D317/28
摘要： The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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公开(公告)号：EP2224912B1
公开(公告)日：2016-05-11
申请号：EP08866209.3
申请日：2008-12-31
申请人： TEKMIRA Pharmaceuticals Corporation , THE UNIVERSITY OF BRITISH COLUMBIA , Alnylam Pharmaceuticals
发明人： HOPE, Michael, J. , SEMPLE, Sean, C. , CHEN, Jianxin , MADDEN, Thomas, D. , MUI, Barbara , CULLIS, Pieter, R. , CIUFOLINI, Marco, A. , WONG, Kim, F. , MANOHARAN, Muthiah , RAJEEV, Kallanthottathil, G. , SRINIVASULU, Masunu
IPC分类号： A61K9/127 , A61K31/7088 , C07D317/28 , C07C229/30
CPC分类号： A61K31/7088 , A61K9/127 , A61K9/1275 , C07C215/10 , C07C217/08 , C07C217/28 , C07C219/08 , C07C229/12 , C07C271/12 , C07C323/25 , C07D317/28
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3.发明公开IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS 有权FOR DELIVERY NUCLEIC改善aminolipids和方法
公开(公告)号：EP2350043A1
公开(公告)日：2011-08-03
申请号：EP09819991.2
申请日：2009-10-09
发明人： HOPE, Michael, J. , SEMPLE, Sean, C. , CHEN, Jianxin , MADDEN, Thomas, D. , CULLIS, Pieter, R. , CIUFOLINI, Marco, A. , MUI, Barbara
IPC分类号： C07D345/00 , C07D517/00 , A61K9/127
CPC分类号： A61K47/22 , A61K9/1271 , A61K31/713 , A61K39/39 , A61K2039/55511 , C07D317/28 , C07D319/06
摘要： The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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公开(公告)号：EP2350043B9
公开(公告)日：2014-08-20
申请号：EP09819991.2
申请日：2009-10-09
发明人： HOPE, Michael, J. , SEMPLE, Sean, C. , CHEN, Jianxin , MADDEN, Thomas, D. , CULLIS, Pieter, R. , CIUFOLINI, Marco, A. , MUI, Barbara
IPC分类号： C07D345/00 , C07D517/00 , A61K9/127
CPC分类号： A61K47/22 , A61K9/1271 , A61K31/713 , A61K39/39 , A61K2039/55511 , C07D317/28 , C07D319/06
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5.发明授权IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS 有权FOR DELIVERY NUCLEIC改善aminolipids和方法
公开(公告)号：EP2350043B1
公开(公告)日：2014-03-26
申请号：EP09819991.2
申请日：2009-10-09
发明人： HOPE, Michael, J. , SEMPLE, Sean, C. , CHEN, Jianxin , MADDEN, Thomas, D. , CULLIS, Pieter, R. , CIUFOLINI, Marco, A. , MUI, Barbara
IPC分类号： C07D345/00 , C07D517/00 , A61K9/127
CPC分类号： A61K47/22 , A61K9/1271 , A61K31/713 , A61K39/39 , A61K2039/55511 , C07D317/28 , C07D319/06
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公开(公告)号：EP2512449A1
公开(公告)日：2012-10-24
申请号：EP10838298.7
申请日：2010-12-17
发明人： HOPE, Michael, J. , MADDEN, Thomas, D. , CULLIS, Pieter , MAIER, Martin, A. , JAYARAMAN, Muthusamy , RAJEEV, Kallanthottathil, G. , AKINC, Akin , MANOHARAN, Muthiah
CPC分类号： A61K47/543 , A61K9/1272 , A61K47/6911 , C12N15/88
摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.
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公开(公告)号：EP0859599B1
公开(公告)日：2003-04-23
申请号：EP96932412.8
申请日：1996-10-09
发明人： LIM, Howard, J. , MADDEN, Thomas, D. , BALLY, Marcel, B. , BARBER, Lana, W. , CHANG, Charmaine, W.
IPC分类号： A61K9/127 , A61K31/135
CPC分类号： A61K31/137 , A61K9/127 , A61K9/1271
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公开(公告)号：EP0783297B1
公开(公告)日：1999-03-24
申请号：EP95932594.5
申请日：1995-10-02
CPC分类号： A61K9/1272 , A61K47/60 , C08G65/329 , Y10S424/812 , Y10S514/885
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9.发明公开POLYETHYLENE GLYCOL MODIFIED CERAMIDE LIPIDS AND LIPOSOME USES THEREOF 失效用聚乙二醇MIDIFIZIERTEN CERAMIDENLIPIDEN和脂质体和用途
公开(公告)号：EP0783297A1
公开(公告)日：1997-07-16
申请号：EP95932594.0
申请日：1995-10-02
CPC分类号： A61K9/1272 , A61K47/60 , C08G65/329 , Y10S424/812 , Y10S514/885
摘要： The present invention provides a novel class of polyethylene glycol modified ceramide lipids. The lipids can be used to form liposomes optionally containing various biological agents or drugs, such as anti-cancer agents. In addition, methods of use for the liposomes are provided.
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公开(公告)号：EP0859599A1
公开(公告)日：1998-08-26
申请号：EP96932412.0
申请日：1996-10-09
发明人： LIM, Howard, J. , MADDEN, Thomas, D. , BALLY, Marcel, B. , BARBER, Lana, W. , CHANG, Charmaine, W.
CPC分类号： A61K31/137 , A61K9/127 , A61K9/1271
摘要： Compositions and methods which are useful for the treatment of solid tumors in a host and which are also useful for increasing the therapeutic index of mitoxantrone in a host. The pharmaceutical compositions are liposomal formulations of mitoxantrone in which the liposomes comprise a mixture of cholesterol and a diacylphosphatidylcholine, preferably 1,2-sn-dimyristoyl-phosphatidylcholine.
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