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    METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES
    1.
    发明公开
    METHODS OF TREATING AND IMAGING TUMOR MICROMETASTASES USING PHOTOACTIVATABLE IMMUNOCONJUGATES 审中-公开
    VERFAHREN ZUR BEHANDLUNG ANDD BILDGEBUNG VON TUMORMIKROMETASTASEN MITTELS LICHTAKTIVIERBARER IMMUNKONJUGATE

    公开(公告)号：EP3099325A4

    公开(公告)日：2017-10-04

    申请号：EP15743124

    申请日：2015-02-02

    申请人： THE GENERAL HOSPITAL CORP DBA MASSACHUSETTS GENERAL HOSPITAL

    发明人： HASAN TAYYABA ,  SPRING BRYAN Q ,  PALANASAMI AKILAN

    IPC分类号： A61K41/00 ,  A61K49/00 ,  A61P35/04 ,  G01J1/48

    CPC分类号： A61B5/0071 ,  A61B1/00009 ,  A61B1/00057 ,  A61B1/043 ,  A61B5/4325 ,  A61B5/7203 ,  A61B5/725 ,  A61K41/0057 ,  A61K49/0036 ,  A61K49/0058 ,  G01J1/48

    摘要： Methods for evaluating micrometastases in a tissue region of a subject are described. The methods include administering to the subject a detectably effective amount of a tumor-targeted photoactivatable immunoconjugate; allowing a sufficient amount of time for the tumor-targeted photoactivatable immunoconjugate to enter micrometastases in the tissue region; illuminating the tumor-targeted photoactivatable immunoconjugate; obtaining an image of the tissue region of the subject using a fluorescent imaging device, and evaluating the micrometastases in the tissue region by conducting algorithmic analysis of the image. Methods of treating micrometastases in a tissue region of a subject are also described.

    摘要翻译： 描述了用于评估受试者的组织区域中的微转移的方法。 所述方法包括向受试者施用可检测有效量的肿瘤靶向光可激活免疫缀合物; 允许足够的时间用于肿瘤靶向的可光活化的免疫缀合物进入组织区域中的微转移; 照亮肿瘤靶向的可光活化的免疫缀合物; 使用荧光成像装置获得对象的组织区域的图像，并通过对图像进行算法分析来评估组织区域中的微转移。 还描述了在受试者的组织区域中治疗微转移的方法。

    SENSOR ZUR STRAHLUNGSENERGIEBESTIMMUNG UND VERWENDUNG HIERFÜR
    2.
    发明公开
    SENSOR ZUR STRAHLUNGSENERGIEBESTIMMUNG UND VERWENDUNG HIERFÜR 审中-公开
    传感器辐射能量确定及其用途

    公开(公告)号：EP1405144A1

    公开(公告)日：2004-04-07

    申请号：EP02751097.3

    申请日：2002-07-02

    申请人： CARL ZEISS SEMICONDUCTOR MANUFACTURING TECHNOLOGIES AG

    发明人： FIOLKA, Damian

    IPC分类号： G03F7/20 ,  G01J1/48

    CPC分类号： G03F7/70558 ,  G01J1/48 ,  Y10T436/206664

    摘要： The invention relates to a sensor for determining the radiated energy of a type which is capable of converting oxygen into ozone, and to the use of said sensor. According to the invention, the sensor contains a measuring chamber (1) which can be penetrated by radiation, comprising a gas inlet (4) and a gas outlet (6), means (8) for supplying gas (9) containing oxygen into the measuring chamber by the gas inlet and for supplying gas into the measuring chamber via the gas inlet and means for discharging said gas via the outlet, an ozone element (10) for measuring the ozone content of the gas (9a) in the measuring chamber or the gas (9a) discharged via the gas outlet, and evaluating means (12) for determining the radiation energy from the measured ozone content. The sensor can, for example, be used for determining the radiation energy in an optical imaging system working with said rays. Said sensor can be used, for example, in a microlithography-projection exposure system.

    UV sensor
    3.
    发明公开
    UV sensor 有权
    UV传感器

    公开(公告)号：EP2916115A3

    公开(公告)日：2015-12-02

    申请号：EP15150548.4

    申请日：2015-01-09

    申请人： Samsung Electronics Co., Ltd

    发明人： Cho, Seong-Je ,  KimIM, Kwang-Bok ,  Cho, Jae-Geol ,  Kim, Jae-Hong ,  Jung, Sun-Tae ,  Cho, Chul-HO

    IPC分类号： G01J1/50 ,  G01J1/42 ,  G01J1/04 ,  G01J1/06 ,  G01J1/48 ,  G01J1/02

    CPC分类号： G01J1/0488 ,  G01J1/0209 ,  G01J1/0414 ,  G01J1/0418 ,  G01J1/0425 ,  G01J1/06 ,  G01J1/429 ,  G01J1/48 ,  G01J1/50

    摘要： An optical sensor and an electronic device having an optical sensor. The optical sensor includes: an optical waveguide containing a photochromic material; a light emitter that emits visible light to be incident on the optical waveguide; and a light receiver that detects the visible light emitted from the light emitter and progressing through the optical waveguide. A transmittance of the optical waveguide in relation to the visible light may be changed by the photochromic material as the optical waveguide is exposed to UV light. The optical sensor and the electronic device having the same may be variously implemented according to exemplary embodiments.

    摘要翻译： 具有光学传感器的光学传感器和电子设备。 光学传感器包括：含有光致变色材料的光波导; 发射入射在光波导上的可见光的发光体; 以及光接收器，其检测从光发射器发射并且通过光波导发出的可见光。 当光波导暴露于紫外光下时，光波导相对于可见光的透射率可以由光致变色材料改变。 根据示例性实施例，光学传感器和具有该光学传感器和电子设备的电子设备可以被不同地实现。

    DYE DESORPTION MOLECULAR INDICATOR
    6.
    发明公开
    DYE DESORPTION MOLECULAR INDICATOR 审中-公开
    分子指标解吸的着色剂

    公开(公告)号：EP1097366A4

    公开(公告)日：2002-09-04

    申请号：EP99938720

    申请日：1999-07-09

    申请人： CHEMMOTIF INC

    发明人： SPITLER MARK T ,  STUHL LOUIS S

    IPC分类号： G01J1/48 ,  G01N21/78 ,  G01N21/00 ,  G01N21/01 ,  G01N21/29 ,  G01N21/64 ,  G01N21/75

    CPC分类号： G01J1/48 ,  G01N21/78

    摘要： A method of broad screen detection, competitive dye desorption from a solid adsorbent, is described for quantifying the presence of a molecule or target analyte in the vapor phase, in solution, or eluted from a solid. In the function of an analytical element for implementing the competitive dye desorption method of the invention, dye or dye-precursor molecules adsorbed on the surface of an adsorbent are caused to desorb through the adsorption of the target analyte on the adsorbent. The desorbed dye or precursor is made detectable through sequestering of a radiation detectable species in the device of the invention. Such detection may occur, e.g., through absorption or emission of radiation in regions of the spectrum extending from the ultra-violet through the visible and into the infra-red regions. In one aspect of the invention, these processes occur within a multi-layer analytical element, in which the functions of the device may be executed by different layers.

    Strahlungsermittlungsvorrichtung
    10.
    发明公开
    Strahlungsermittlungsvorrichtung 失效
    辐射检测装置

    公开(公告)号：EP1193481A3

    公开(公告)日：2002-04-17

    申请号：EP01124092.6

    申请日：1997-03-18

    申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts

    发明人： Gross, Karlheinz, Dipl. Biologe, Dipl. Physiker ,  Stehle, Gerd, Dr.

    IPC分类号： G01J1/58 ,  G01T1/20

    CPC分类号： G01J1/58 ,  G01J1/48 ,  G01R33/28 ,  G01T1/20

    摘要： Die Erfindung betrifft eine Vorrichtung zum Ermitteln von Eingangsstrahlung, z.B. Röntgen-, γ-, ionisierende Strahlung bzw. Fluoreszenz- oder Restlicht, mit mindestens einem Erfassungselement, das einen Sensorteil (Szintillator) zur Umwandlung der Eingangsstrahlung in im UV-, sichtbaren oder IR-Teil des elektromagnetischen Spektrums liegende Photonen (Szinillationslicht) und einen optischen Verstärkerteil aufweist, der das vom Sensorteil gewandelte Licht aufnimmt, zur weiteren Verarbeitung weiterleitet und dabei verstärkt. Erfindungsgemäß weist der Verstärkerteil wenigstens einen optischen Lichtwellenleiter 1, 2, 2a, 2b, 20 aufweist, dessen Material zur Verstärkung des Szintillationslichts optisch gepumpt 3, 24, 25 ist.