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公开(公告)号：EP1203075A1
公开(公告)日：2002-05-08
申请号：EP00943034.9
申请日：2000-06-21
发明人： COSMAN, Maury, D. , DIMILLA, Paul, A. , TONER, Mehmet , YARMUSH, Martin, L. , BALIS, Ulysses, J. , TILLES, Arno, W.
CPC分类号： A61M1/3472 , A61F2/022 , A61M1/3482 , A61M1/3489 , A61M1/3633 , A61M2210/1071 , C12M23/24 , C12M29/04 , C12M29/10 , C12N5/0068 , C12N5/0671
摘要： The invention features modular cell culturing devices (1) including one or more flat - plate modules (2), and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices (1) can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver assist systems, for production of cells, for production of cell-derived products, such as proteins or viruses, or for systems to treat biological liquid to remove toxins, such as ammonia, or add cell-synthesized products, or both.
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公开(公告)号：EP1203075B1
公开(公告)日：2007-09-12
申请号：EP00943034.9
申请日：2000-06-21
发明人： COSMAN, Maury, D. , DIMILLA, Paul, A. , TONER, Mehmet , YARMUSH, Martin, L. , BALIS, Ulysses, J. , TILLES, Arno, W.
CPC分类号： A61M1/3472 , A61F2/022 , A61M1/3482 , A61M1/3489 , A61M1/3633 , A61M2210/1071 , C12M23/24 , C12M29/04 , C12M29/10 , C12N5/0068 , C12N5/0671
摘要： The invention features modular cell culturing devices (1) including one or more flat - plate modules (2), and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated by a gas-permeable, liquid-impermeable membrane, and the cells are grown attached to the liquid side of the membrane, the device can be used to culture cells with transport of oxygen through the membrane (i.e., direct oxygenation), without regard for the flow rate of the liquid medium passing through the device. The new flow-through cell culturing devices (1) can thus be used to culture cells, e.g., hepatocytes, with high levels of cell function in organ, e.g., liver assist systems, for production of cells, for production of cell-derived products, such as proteins or viruses, or for systems to treat biological liquid to remove toxins, such as ammonia, or add cell-synthesized products, or both.
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