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    ICE SEEDING APPARATUS FOR CRYOPRESERVATION SYSTEMS
    6.
    发明授权
    ICE SEEDING APPARATUS FOR CRYOPRESERVATION SYSTEMS 失效
    对于系统TIEFKUHLKONSERVIERUNG冰播种设备

    公开(公告)号：EP1012499B1

    公开(公告)日：2006-12-13

    申请号：EP97904153.0

    申请日：1997-01-30

    申请人： ORGANOGENESIS INC.

    发明人： COSMAN, Maury, D.

    IPC分类号： F17C13/02 ,  F17C7/02 ,  F25D25/00 ,  F25D17/02 ,  A47F7/00 ,  A47F5/14 ,  F25D3/10 ,  F25D29/00 ,  A01N1/02 ,  G01N1/42

    CPC分类号： G01N1/42 ,  A01N1/02 ,  A01N1/0257 ,  F25D3/102 ,  F25D25/00 ,  F25D29/001

    摘要： An apparatus for ice seeding during cryopreservation of biological samples such as cells, harvested tissues, and cellular biological constructs such as culture tissue equivalents wherein ice seeding is performed by discharging a liquefied or chilled gas (60) from a nozzle (21) to the surface of a container (40) containing said biological sample in cryopreservative. Inside a freezing chamber (70), containers (40) are placed on racks (30) that are located proximal to a sprayrail (20) containing nozzles (21). Ice seeding is performed by discharge of liquefied or chilled gas (60) from the nozzles to the container surface at the solid-liquid equilibrium temperature of the cryopreservative. Localized cooling of the container surface by the discharge results in ice seed formation within the container (40).

    Bioengineered tissue constructs and methods for producing and using them
    7.
    发明公开
    Bioengineered tissue constructs and methods for producing and using them 有权
    生物技术与生物技术

    公开(公告)号：EP1612265A2

    公开(公告)日：2006-01-04

    申请号：EP05076319.2

    申请日：1999-11-19

    申请人： ORGANOGENESIS INC.

    发明人： Murphy, Michael P. ,  Ronfard, Vincent

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0698 ,  A61K35/12 ,  C12N2500/90 ,  C12N2502/094 ,  C12N2502/1323

    摘要： Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of multiple cell layers or more than one cell type. The tissue constructs of the invention have morphological features and functions similar to tissues and their strength makes them easily handleable. Preferred cultured tissue constructs of the invention are prepared in defined media, that is, without the addition of chemically undefined components.

    摘要翻译： 包含培养细胞和内生产生的细胞外基质组分的培养组织构建体，而不需要外源基质组分或网络支持物或支架构件。 本发明的一些组织构建体由多个细胞层或多于一种细胞类型组成。 本发明的组织构造具有类似于组织的形态特征和功能，并且其强度使得它们易于处理。 在限定的培养基中制备本发明优选的培养的组织构建体，即不添加化学未定义的组分。