公开(公告)号：EP2783018A2

公开(公告)日：2014-10-01

申请号：EP12851735.6

申请日：2012-11-21

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a neutralizer in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins, and small molecules. In certain embodiments the neutralizer forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

公开(公告)号：EP3467487A1

公开(公告)日：2019-04-10

申请号：EP18204439.6

申请日：2012-01-11

申请人： The Governing Council of the University of Toronto

发明人： DAS, Jagotamoy ,  KELLEY, Shana, O.

IPC分类号： G01N27/327 ,  G01N33/543

摘要： Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.

公开(公告)号：EP3147372A3

公开(公告)日：2017-04-26

申请号：EP16185746.1

申请日：2012-11-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a pseudoligand in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins and small molecules. In certain embodiments, the pseudoligand forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

摘要翻译： 考虑的方法和装置包括在电化学检测广泛范围的分析物（包括核酸，蛋白质和小分子）中使用带电探针和伪配体。 在某些实施方案中，伪配体与探针形成复合物，其与探针本身相比具有降低的电荷量，并且当复合物暴露于分析物时，其与探针置换。

公开(公告)号：EP2783018B1

公开(公告)日：2016-09-07

申请号：EP12851735.6

申请日：2012-11-21

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

公开(公告)号：EP2663857A2

公开(公告)日：2013-11-20

申请号：EP12734237.6

申请日：2012-01-11

申请人： The Governing Council of the University of Toronto

发明人： DAS, Jagotamoy ,  KELLEY, Shana, O.

IPC分类号： G01N27/30 ,  G01N33/483

CPC分类号： G01N33/5438 ,  G01N27/3277 ,  G01N33/54353

摘要： Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.

公开(公告)号：EP4115176A1

公开(公告)日：2023-01-11

申请号：EP21764464.0

申请日：2021-03-02

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana ,  SARGENT, Edward ,  DAS, Jagotamoy ,  GOMIS, Surath ,  CHEN, Jenise B. ,  AHMED, Sharif ,  YOUSEFI, Hanie ,  CHANG, Dingran ,  MAHMUD, Alam

IPC分类号： G01N27/327 ,  C12M1/34 ,  C12Q1/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N27/416 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/569 ,  G01N27/403

公开(公告)号：EP2663857B1

公开(公告)日：2018-12-12

申请号：EP12734237.6

申请日：2012-01-11

申请人： The Governing Council of the University of Toronto

发明人： DAS, Jagotamoy ,  KELLEY, Shana, O.

IPC分类号： G01N27/327 ,  G01N33/543

CPC分类号： G01N33/5438 ,  G01N27/3277 ,  G01N33/54353

摘要： Described herein are systems and methods for detecting a target analyte in a sample with electrodes, comprising a linker and an antibody attached to the linker, and measuring an electrocatalytic signal changes generated by binding of an analyte in the sample to the antibody. Also disclosed herein are kits for electrochemical detection of protein analytes.

公开(公告)号：EP3147372A2

公开(公告)日：2017-03-29

申请号：EP16185746.1

申请日：2012-11-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a pseudoligand in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins and small molecules. In certain embodiments, the pseudoligand forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.