公开(公告)号：EP2783018A2

公开(公告)日：2014-10-01

申请号：EP12851735.6

申请日：2012-11-21

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a neutralizer in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins, and small molecules. In certain embodiments the neutralizer forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

公开(公告)号：EP3147372A2

公开(公告)日：2017-03-29

申请号：EP16185746.1

申请日：2012-11-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a pseudoligand in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins and small molecules. In certain embodiments, the pseudoligand forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

公开(公告)号：EP3147372A3

公开(公告)日：2017-04-26

申请号：EP16185746.1

申请日：2012-11-21

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94

摘要： Contemplated methods and devices comprise use of a charged probe and a pseudoligand in the electrochemical detection of a wide range of analytes, including nucleic acids, proteins and small molecules. In certain embodiments, the pseudoligand forms a complex with the probe that has a reduced charge magnitude compared to the probe itself, and is displaced from the probe when the complex is exposed to the analyte.

摘要翻译： 考虑的方法和装置包括在电化学检测广泛范围的分析物（包括核酸，蛋白质和小分子）中使用带电探针和伪配体。 在某些实施方案中，伪配体与探针形成复合物，其与探针本身相比具有降低的电荷量，并且当复合物暴露于分析物时，其与探针置换。

公开(公告)号：EP2783018B1

公开(公告)日：2016-09-07

申请号：EP12851735.6

申请日：2012-11-21

申请人： The Governing Council of the University of Toronto

发明人： KELLEY, Shana, O. ,  ZARAGOZA, Alexandre ,  SARGENT, Edward, Hartley ,  DAS, Jagotamoy ,  CEDERQUIST, Kristin

IPC分类号： C12Q1/68 ,  G01N33/543

CPC分类号： G01N27/3275 ,  C12Q1/6818 ,  C12Q1/6825 ,  C12Q2525/107 ,  C12Q2527/146 ,  G01N27/327 ,  G01N27/3277 ,  G01N27/4145 ,  G01N33/54373 ,  G01N33/5438 ,  G01N33/94