公开(公告)号：EP0759992B1

公开(公告)日：2004-10-27

申请号：EP95920437.1

申请日：1995-05-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF REGENTS FOR NORTHERN ILLINOIS UNIVERSITY

发明人： HAMPEL, Arnold ,  DIPAOLO, Joseph ,  SIWKOWSKI, Andrew

IPC分类号： C12N15/52 ,  C12N9/00 ,  A61K31/70 ,  C12Q1/68

CPC分类号： C12N15/1131 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/122 ,  C12N2799/027 ,  C12Q1/683 ,  C12Q1/708 ,  C12Q2521/337

公开(公告)号：EP0759992A1

公开(公告)日：1997-03-05

申请号：EP95920437.0

申请日：1995-05-15

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  THE BOARD OF REGENTS FOR NORTHERN ILLINOIS UNIVERSITY

发明人： HAMPEL, Arnold ,  DIPAOLO, Joseph ,  SIWKOWSKI, Andrew

IPC分类号： C12N15 ,  C12Q1 ,  A61K38 ,  A61K48

CPC分类号： C12N15/1131 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/122 ,  C12N2799/027 ,  C12Q1/683 ,  C12Q1/708 ,  C12Q2521/337

摘要： Synthetic ribozymes, i.e. ribozymes including a hairpin portion, binding sites for binding to a human papilloma virus (HPV) after viral base 419 or 434, respectively, and cleavage sites for cleaving HPV virus are disclosed. The invention also includes a diagnostic assay for determining the presence of HPV-16 in tissues based on PCR amplification.