专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"BARRY, Clifton, E., III" 第 1 页

1.

发明公开
METHOD OF ATTENUATING PATHOGENIC MYCOBACTERIA AND STRAINS OF MYCOBACTERIA SO ATTENUATED 失效
标题翻译：头发剪方法联合国 - DEVICE

公开(公告)号：EP0994944A1

公开(公告)日：2000-04-26

申请号：EP98933285.3

申请日：1998-07-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： BARRY, Clifton, E., III , YUAN, Ying , CRANE, Deborah

IPC分类号： C12N15/01 , C12N1/36 , A61K39/04 , C07K14/35

CPC分类号： C12R1/32 , A61K39/04 , A61K2039/521 , C07K14/35 , Y10S435/863 , Y10S435/864 , Y10S435/865 , Y10S435/866

摘要： This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by eliminating or by downregulating the expression of the α-crystallin heat shock protein gene ('acr gene'). The invention provides for vaccines and methods of vaccinating mammals for protection against Mycobacterium sp. that cause tuberculosis.