专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES" OR "NESTEC S.A.") AND inv:"GONZALEZ, Frank, J." 第 1 页

1.

发明公开
IMMORTALIZED HUMAN CELL LINES CONTAINING EXOGENOUS CYTOCHROME P450 GENES 失效
标题翻译：含有外源的永生化的细胞色素P450基因的人细胞系。

公开(公告)号：EP0640137A1

公开(公告)日：1995-03-01

申请号：EP93912165.0

申请日：1993-04-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , NESTEC S.A.

发明人： HARRIS, Curtis, C. , GELBOIN, Harry, V. , GONZALEZ, Frank, J. , PFEIFER, Andrea, M., A.

IPC分类号： C07K14 , C12N9 , C12N15 , G01N33

CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0077 , C12N15/86 , C12N2500/90 , C12N2710/24143 , G01N33/5011 , G01N33/5017

摘要： Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, and chemotherapeutic agents utilizing these cell lines.

2.

发明授权
IMMORTALIZED HUMAN CELL LINES CONTAINING EXOGENOUS CYTOCHROME P450 GENES 失效
标题翻译：外源性细胞色素P450基因含永生化人细胞系

公开(公告)号：EP0640137B1

公开(公告)日：2003-11-19

申请号：EP93912165.3

申请日：1993-04-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , NESTEC S.A.

发明人： HARRIS, Curtis, C. , GELBOIN, Harry, V. , GONZALEZ, Frank, J. , PFEIFER, Andrea, M., A.

IPC分类号： C12N15/53 , C12N5/10 , C12Q1/26 , G01N33/50

CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0077 , C12N15/86 , C12N2500/90 , C12N2710/24143 , G01N33/5011 , G01N33/5017

摘要： Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, and chemotherapeutic agents utilizing these cell lines.

3.

发明授权
METHODS AND COMPOSITIONS FOR DETECTING DIHYDROPYRIMIDINE DEHYDROGENASE SPLICING MUTATIONS 失效
标题翻译：方法和组合物剪接突变的DIHYDROPYREMUDINE脱氢酶检测

公开(公告)号：EP0896629B8

公开(公告)日：2003-01-02

申请号：EP97915143.8

申请日：1997-03-19

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services

发明人： GONZALEZ, Frank, J. , FERNANDEZ-SALGUERO, Pedro

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 , C12Q2539/105

摘要： The present invention provides compositions, methods and kits for the detection of genetic polymorphisms or mutations related to dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphism or mutations generally occur in the dihydropyrimidine dehydrogenase DPD gene in chromosome 1. Also provided are mutant forms of DPD.