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1.发明授权
公开(公告)号：EP0640137B1
公开(公告)日：2003-11-19
申请号：EP93912165.3
申请日：1993-04-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , NESTEC S.A.
CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0077 , C12N15/86 , C12N2500/90 , C12N2710/24143 , G01N33/5011 , G01N33/5017
摘要： Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, and chemotherapeutic agents utilizing these cell lines.
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2.发明公开IMMORTALIZED HUMAN CELL LINES CONTAINING EXOGENOUS CYTOCHROME P450 GENES 失效含有外源的永生化的细胞色素P450基因的人细胞系。
公开(公告)号：EP0640137A1
公开(公告)日：1995-03-01
申请号：EP93912165.0
申请日：1993-04-09
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , NESTEC S.A.
CPC分类号： C12N9/0071 , C07K14/80 , C12N9/0077 , C12N15/86 , C12N2500/90 , C12N2710/24143 , G01N33/5011 , G01N33/5017
摘要： Non-tumorigenic, human bronchial epithelial cell lines are provided wherein the cell lines are capable of expressing cytochrome P450 genes which have been inserted into the cell lines. Also provided are methods and kits for identifying potential mutagens, cytotoxins, carcinogens, and chemotherapeutic agents utilizing these cell lines.
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3.发明公开METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF ESPHAGEAL ADENOCARCINOMAS 审中-公开方法和组合物的诊断和治疗食管腺癌
公开(公告)号：EP2212440A1
公开(公告)日：2010-08-04
申请号：EP08838376.5
申请日：2008-10-10
申请人： The Ohio State University Research Foundation , The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/178
摘要： Methods and compositions for the diagnosis, prognosis and/or treatment of esophageal adenocarcinoma and Barrett's esophagus associated adenocarcinoma are disclosed, along with more markers where a difference is indicative of esophageal adenocarcinoma and squamous cell carcinoma, and/or Barrett's esophagus associated adenocarcinomas or a predisposition thereto. The invention also provides methods and compositions of identifying anti-cancer agents therefor.
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公开(公告)号：EP2041313B1
公开(公告)日：2011-03-23
申请号：EP07799622.1
申请日：2007-07-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-lα, IL-Ib, IL-2, IL-8, IL-IO, IL- 12, IL-15, IFN-γ and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-la, IL-Ib, IL-2, IL-8, IL-IO, IL-12, IL-15, IFN-γ and TNF- a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.
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公开(公告)号：EP2401405A1
公开(公告)日：2012-01-04
申请号：EP10746739.1
申请日：2010-02-24
申请人： The Ohio State University Research Foundation , The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12N15/113 , C12N15/1138 , C12N2310/113 , C12N2310/141 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer in never- smokers. The invention also provides methods of identifying anti-lung cancer agents.
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6.发明公开MICRO-RNA-BASED METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF COLON CANCER-RELATED DISEASES 审中-公开MICRO-RNA为基础的与癌症相关的诊断和治疗疾病的组合物和方法
公开(公告)号：EP2041317A2
公开(公告)日：2009-04-01
申请号：EP07810382.7
申请日：2007-07-12
申请人： The Ohio State University Research Foundation , The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
摘要： The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.
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公开(公告)号：EP2041313A2
公开(公告)日：2009-04-01
申请号：EP07799622.1
申请日：2007-07-16
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136
摘要： Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-lα, IL-Ib, IL-2, IL-8, IL-IO, IL- 12, IL-15, IFN-γ and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-la, IL-Ib, IL-2, IL-8, IL-IO, IL-12, IL-15, IFN-γ and TNF- a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.
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