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    Use of pharmaceutical compositions comprising cyclohexane derivatives in the treatment or prevention of peptic ulcers
    1.
    发明公开
    Use of pharmaceutical compositions comprising cyclohexane derivatives in the treatment or prevention of peptic ulcers 失效
    使用环孢菌素衍生物在治疗或预防皮肤溃疡中的药物组合物的使用

    公开(公告)号：EP0282643A3

    公开(公告)日：1990-08-22

    申请号：EP87117155.9

    申请日：1987-11-20

    申请人： THE GREEN CROSS CORPORATION

    发明人： Fukaya, Chikara ,  Yasuda, Hitoshi ,  Akira, Toshiaki ,  Iwai, Masakazu ,  Okano, Kanemichi ,  Yokoyama, Kazumasa

    IPC分类号： A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70

    CPC分类号： A61K31/7004 ,  A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70 ,  C07C47/192 ,  C07C47/198 ,  C07C49/11 ,  C07C49/172 ,  C07C49/175 ,  C07C49/497 ,  C07C49/517 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I):
    wherein A represents a group shown by formula, >CH₂,
    X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group;
    R¹, R³, R⁴ and R⁵ each represents a hydrogen atom or substituted or un­substituted alkyl; R² represents a hydrogen atom or substituted or unsubstituted alkyl or a group shown by -OR⁸; R⁶ represents a hydrogen atom, oxo or a group shown by -OR⁸; R⁷ represents a hydrogen atom or a group shown by -OR⁸, and R⁸ represents a hydrogen atom or an organic residue, and a pharmaceutically acceptable additive. Such derivatives are also provided for use as a medicament, particularly for the treatment or prevention of peptic ulcers. The use of such derivatives for the manufacture of a medicament having therapeutic and preventative value is also provided.

    摘要翻译： 包含作为有效成分的通式（I）表示的环己烷衍生物的消化性溃疡的治疗和预防剂：其中A表示式CH 2所示的基团，X表示亚乙炔基，亚乙烯基或亚乙基， Y表示氧代或羟基; R 1，R 3，R 4和R 5各自表示氢原子或取代或未取代的烷基; R 2表示氢原子或取代或未取代的烷基或-OR 8所示的基团; R 6表示氢原子，氧代或-OR 8所示的基团; R 7表示氢原子或-OR 8所示的基团，R 8表示氢原子或有机残基，以及药学上可接受的添加剂。 这些衍生物还提供用作药物，特别是用于治疗或预防消化性溃疡。 还提供了这种衍生物用于制备具有治疗和预防价值的药物的用途。

    Use of pharmaceutical compositions comprising cyclohexane derivatives in the treatment or prevention of peptic ulcers
    2.
    发明公开
    Use of pharmaceutical compositions comprising cyclohexane derivatives in the treatment or prevention of peptic ulcers 失效
    使用在胃溃疡的治疗或预防的药物组合物的环己烷衍生物。

    公开(公告)号：EP0282643A2

    公开(公告)日：1988-09-21

    申请号：EP87117155.9

    申请日：1987-11-20

    申请人： THE GREEN CROSS CORPORATION

    发明人： Fukaya, Chikara ,  Yasuda, Hitoshi ,  Akira, Toshiaki ,  Iwai, Masakazu ,  Okano, Kanemichi ,  Yokoyama, Kazumasa

    IPC分类号： A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70

    CPC分类号： A61K31/7004 ,  A61K31/045 ,  A61K31/075 ,  A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/70 ,  C07C47/192 ,  C07C47/198 ,  C07C49/11 ,  C07C49/172 ,  C07C49/175 ,  C07C49/497 ,  C07C49/517 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers comprising as an effective ingredient a cyclohexane derivative represented by general formula (I):
    wherein A represents a group shown by formula, >CH₂,
    X represents ethynylene, vinylene or ethylene, Y represents oxo or a hydroxy group;
    R¹, R³, R⁴ and R⁵ each represents a hydrogen atom or substituted or un­substituted alkyl; R² represents a hydrogen atom or substituted or unsubstituted alkyl or a group shown by -OR⁸; R⁶ represents a hydrogen atom, oxo or a group shown by -OR⁸; R⁷ represents a hydrogen atom or a group shown by -OR⁸, and R⁸ represents a hydrogen atom or an organic residue, and a pharmaceutically acceptable additive.
    Such derivatives are also provided for use as a medicament, particularly for the treatment or prevention of peptic ulcers.
    The use of such derivatives for the manufacture of a medicament having therapeutic and preventative value is also provided.

    摘要翻译： 用于治疗消化性溃疡，其包含如上有效成分的治疗和预防剂的环己烷衍生物由通式（I）表示： worin甲darstellt由式所示的基团，> CH 2， X darstellt亚乙炔基，亚乙烯基或亚乙基， ÿdarstellt氧代或羟基; [R <1>，R <3>，R <4>和R <5>每个darstellt氢原子或substituiertem奥德unsubstituiertem烷基; [R <2>代表氢原子或substituiertem奥德unsubstituiertem烷基或-O-R <8>所示的基团; [R <6>代表氢原子，氧代基或-O-R <8>所示的基团; [R <7> darstellt氢原子或由-OR <8>所示的基团，并且R <8> darstellt氢原子或添加剂的有机残基，和药学上可接受的。 因此，提供用作药物的搜索衍生物，特别是用于治疗消化性溃疡的治疗或预防。 利用衍生的搜索具有治疗和预防价值的药物中的用途因此，提供。