公开(公告)号：EP2994447B1

公开(公告)日：2020-04-08

申请号：EP14721401.9

申请日：2014-05-05

申请人： Firmenich SA

发明人： INDRADAS, Brinda ,  VIRTUCIO, Gilbert ,  WOMACK, Gary

IPC分类号： C07C29/50 ,  C07C31/125 ,  C07C33/02 ,  C07C33/025 ,  C07C33/03 ,  C07C33/20 ,  C07C35/06 ,  C07C43/215 ,  C07C43/23 ,  C07C45/36 ,  C07C45/37 ,  C07C47/232 ,  C07C47/54 ,  C07C47/542 ,  C07C47/575 ,  C07C67/39 ,  C07C69/06 ,  C07C69/07 ,  C11B9/00

公开(公告)号：EP3237365B1

公开(公告)日：2018-11-28

申请号：EP15810749.0

申请日：2015-12-18

申请人： Rhodia Operations

发明人： CHOUZIER, Sandra ,  OCAMPO, Fabien ,  MASTROIANNI, Sergio ,  CORMA, Avelino ,  BORONAT, Mercedes ,  LÓPEZ AUSENS, Javier Tirso

IPC分类号： C07C29/48 ,  C07C45/28 ,  C07C35/06 ,  C07C35/08 ,  C07C29/132 ,  C07C45/53 ,  C07C51/31

CPC分类号： C07C51/316 ,  C07C29/132 ,  C07C29/48 ,  C07C45/28 ,  C07C45/53 ,  C07C407/00 ,  C07C2601/14 ,  C08G69/28 ,  C07C35/06 ,  C07C35/08 ,  C07C35/02 ,  C07C49/395 ,  C07C49/403 ,  C07C49/385

摘要： The present invention concerns a method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with a hydroperoxide compound in the presence of a catalytic effective amount of a cerium oxide based catalyst.

公开(公告)号：EP2234948B1

公开(公告)日：2011-08-31

申请号：EP09704459.8

申请日：2009-01-20

申请人： Firmenich S.A.

发明人： MORETTI, Robert

IPC分类号： C07C35/06 ,  C07C35/17 ,  C11B9/00

CPC分类号： C11B9/003 ,  C07C35/06 ,  C07C2601/08 ,  C11B9/0034

摘要： The present invention relates to the field of perfumery. More particularly, it concerns specific derivatives of 1-alkenyl cyclopentanol, or 1-alkenyl cyclohexanol, wherein the alkenyle group is branched. These compounds are useful perfuming ingredients capable of imparting sap and/or earthy notes.

公开(公告)号：EP2218788A1

公开(公告)日：2010-08-18

申请号：EP10005543.3

申请日：2006-01-18

申请人： Chirogate International Inc.

发明人： Wei, Shih-Yi ,  Yeh, Yu-Chih ,  Hsu, Ming-Kun

IPC分类号： C12P7/38 ,  C12P41/00 ,  C07C35/06 ,  C07D295/08 ,  C07D317/54 ,  C07D295/00

CPC分类号： C07D317/54 ,  C07B2200/07 ,  C07C69/738 ,  C07C69/90 ,  C07C2601/10 ,  C07C2601/14 ,  C07D295/088 ,  C12P7/38 ,  C12P41/004

摘要： The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula ( R )-1,

which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

摘要翻译： 本发明涉及制备式（R）-1的光学活性环戊烯酮的新方法，其可用于制备前列腺素及其类似物。 本发明还涉及由该方法制备的新型环戊烯酮。

公开(公告)号：EP1942087A1

公开(公告)日：2008-07-09

申请号：EP06811286.1

申请日：2006-10-05

申请人： Daiichi Sankyo Company, Limited

发明人： SATO, Koji ,  IMAI, Makoto

IPC分类号： C07B35/06 ,  C07B61/00 ,  C07C1/30 ,  C07C15/04 ,  C07C15/58 ,  C07C35/06 ,  C07C67/317 ,  C07C69/74

CPC分类号： C07B35/06 ,  C07C1/30 ,  C07C67/317 ,  C07C2531/24 ,  C07C2601/02 ,  C07C15/04 ,  C07C15/24 ,  C07C69/74

摘要： The present invention relates to a hydrodehalogenation method in which a halogen atom on a carbon atom of an organic compound is removed by substituting the halogen atom with a hydrogen atom, and to a method for producing a dehalogenated compound. The hydrodehalogenation method is characterized by including treating an organic compound having a halogen atom on a carbon atom thereof in a solvent with a compound represented by formula (2-1):

        M 2 BH p R 1 q      (2-1)

or formula (2-2) :

        M 3 (BH p R 1 q ) 2      (2-2)

(wherein M 2 represents an alkali metal atom; M 3 represents an alkaline earth metal atom or a zinc atom; R 1 represents a hydrogen atom, a cyano group, a C2-C13 acyloxy group, or a C1-C6 alkoxy group; p is an integer of 1 to 4; q is an integer of 0 to 3; and the sum of p and q is 4) in the presence of a Group VIII metal complex represented by formula (1):

        M 1 X m L n      (1)

(wherein M 1 represents a Group VIII metal; X represents a halogen atom; L represents a neutral ligand; m is an integer of 1 or 2; n is an integer of 2 or 3; and the sum of m and n is 4).

摘要翻译： 本发明涉及通过用氢原子取代卤原子除去有机化合物的碳原子上的卤素原子的氢化脱卤方法和脱卤化合物的制造方法。 加氢脱卤法的特征在于在溶剂中用式（2-1）表示的化合物处理其碳原子上具有卤素原子的有机化合物：ƒ€ƒ€ƒ€ƒ€ƒ€ ƒM2 BH p R 1 q€ƒ€ƒ€ƒ€ƒ（2-1）或公式（2-2）：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒM3（BH p R 1 q）2€ƒ€ƒ€ƒ（2-2）（其中M 2表示碱金属原子; M 3表示碱土金属原子或锌原子; R 1表示氢原子， 氰基，C 2 -C 13酰氧基或C 1 -C 6烷氧基; p为1〜4的整数，q为0〜3的整数，p和q的和为4） 由式（1）表示的第VIII族金属配合物：ƒ€ƒ€ƒ€ƒ€ƒ€ƒM1 X m L n€€ƒ€ƒ€ƒ（1）（其中M 1表示VIII族金属; X表示卤素原子; L表示中性配体; m表示1或2的整数，n表示2或3的整数，su表示 m的m和n是4）。

公开(公告)号：EP0638077B1

公开(公告)日：2001-09-19

申请号：EP93909073.4

申请日：1993-04-21

申请人： Chirotech Technology Limited

发明人： ROBERTS, Stanley Michael ,  OLIVO, Horacio F. ,  McCAGUE, Raymond

IPC分类号： C07D307/93 ,  C12P41/00 ,  C12P17/04 ,  C07C35/06

CPC分类号： C07D307/935 ,  C07C35/06 ,  C12P17/04 ,  C12P41/004

摘要： An optically-purified enantiomer of the lactone 4-hydroxy-2-oxabicyclo-[3.3.0]oct-7-en-3-one or an acylate thereof can be obtained by biotransformation. It is a useful synthon in the preparation of an enantiomer of 3-hydroxymethyl-2-hydroxycyclopentene that can be used to prepare carbocyclic nucleosides as a desired enantiomer.

公开(公告)号：EP1129057A1

公开(公告)日：2001-09-05

申请号：EP00963345.4

申请日：2000-08-31

申请人： BOULDER SCIENTIFIC COMPANY

发明人： ASKHAM, Fredric, R.

IPC分类号： C07C15/02 ,  C07C29/14 ,  C07C35/06 ,  C07C35/42

CPC分类号： C07F17/00 ,  B01J31/2295 ,  B01J2531/40 ,  C07C13/66 ,  C07C29/143 ,  C07C303/28 ,  C07C2603/40 ,  C07F7/10 ,  C08F10/00 ,  Y10S526/943 ,  C08F4/6592 ,  C07C309/66

摘要： A method of converting Compound A (1,3-dehydro-cyclopenta[1]phenanthren-2-one) to Compound C (1H-cyclopenta[1]phenanthren) in situ in a single reactor is disclosed.

公开(公告)号：EP0585104A1

公开(公告)日：1994-03-02

申请号：EP93306693.8

申请日：1993-08-24

申请人： Japan Tobacco Inc.

发明人： Ebata, Takashi, c/o Japan Tobacco Inc. ,  Koseki, Koshi, c/o Japan Tobacco Inc. ,  Okano, Koji, c/o Japan Tobacco Inc. ,  Kawakami, Hiroshi, c/o Japan Tobacco Inc. ,  Matsumoto, Katsuya, c/o Japan Tobacco Inc. ,  Matsushita, Hajime, c/o Japan Tobacco Inc.

IPC分类号： C07C69/675 ,  C07C67/22 ,  C07D311/00 ,  C07C253/16 ,  C07D307/20 ,  C07D301/02 ,  C07D307/33 ,  C07C35/06 ,  C07C29/147

CPC分类号： C07D307/00 ,  C07C69/675 ,  Y02P20/55

摘要： Disclosed is a method of preparing a saturated monocyclic hydrocarbon compound having high optical purity and an intermediate therefor from an easily available starting material. A vinyl group is introduced to compound (6), which is synthesized from levoglucosenone to obtain compound (7). The double bond of the vinyl group of compound (7) is oxidatively cleaved and a hydroxyl group is protected to obtain compound (9). The obtained compound (9) was intramolecularly alkylated by treating with a base to give compound (10). Then, compound (10) is reduced to give compound (11). The primary hydroxyl group is selectively esterified to obtain the desired saturated monocyclic hydrocarbon compound (1).

where
   R¹, R², and R³ are an alkyl group and an X² group is a leaving group which is possible to remove as OX².

摘要翻译： 本发明公开了制备具有高光学纯度的饱和单环烃化合物的方法，并且在中间为此从容易获得的起始材料。 乙烯基团引入到化合物（6），其是从levoglucosenone合成，以获得化合物（7）。 化合物（7）的乙烯基的双键氧化裂解和羟基基团被保护，得到化合物（9）。 所获得的化合物（9），其分子内通过用碱处理，得到化合物（10）烷基化。 然后，化合物（10）还原，得到化合物（11）。 伯羟基被选择性酯化，得到所需的饱和单环烃化合物（1）。 其中R <1>，R <2>和R <3>是关烷基和X <2>基是离去基团，其全部能够除去作为OX <2>。

公开(公告)号：EP0576834A2

公开(公告)日：1994-01-05

申请号：EP93108575.7

申请日：1993-05-27

申请人： KUREHA KAGAKU KOGYO KABUSHIKI KAISHA

发明人： Takahashi, Eisaku ,  Kimura, Takashi ,  Kumazawa, Satoru

IPC分类号： C12P41/00 ,  C12P7/22 ,  C07D233/60 ,  C07D249/08 ,  C07C35/06 ,  C07C35/48 ,  C07C205/19 ,  C07C255/53 ,  C07C309/63

CPC分类号： C07D231/12 ,  C07B57/00 ,  C07B2200/07 ,  C07C303/28 ,  C07C2601/08 ,  C07D233/56 ,  C07D249/08 ,  C12P7/22 ,  C12P41/004 ,  Y10S435/874 ,  Y10S435/921 ,  C07C309/66

摘要： In the present invention, an optically active cis type 1,2-diol derivative of the following formula (I) is produced by reacting a cis type 1,2-diol derivative of the formula (I) with a carboxylic acid derivative of the formula (II) in the presence of a lipase:



wherein R 1 and R 2 independently represent hydrogen atom or an alkyl group, X represents a halogen atom, a nitro group, a cyano group, an alkyl group, a haloalkyl group, or a phenyl group, and n represents an integer of from 0 to 5; R 3 represents a C 1 - C 10 alkyl group or an aryl group, and R 4 represents a hydrogen atom, a C 1 - C 5 alkyl group, a C 2 - C 4 alkenyl group, or COR 3 .
The cis type means that the bond between the cyclopentane ring and the hydroxy group and the bond between the cyclopentane ring and the benzyl group reside in the same direction as that portrayed on the paper.
The optically active cis type 1,2-diol derivative is used as an intermediate for producing an optically active cis type azole derivative of the formula (VII).

公开(公告)号：EP0297752B1

公开(公告)日：1992-09-16

申请号：EP88305462.9

申请日：1988-06-15

申请人： Takasago International Corporation

发明人： Sayo, Noboru ,  Saito, Takao ,  Kumobayashi Hidenori ,  Akutagawa, Susumu ,  Noyori, Ryoji ,  Takaya, Hidemasa

IPC分类号： C07C29/136 ,  C07C31/20 ,  C07C33/36 ,  C07C67/31 ,  C07C41/26 ,  C07C213/00 ,  C07C35/06 ,  C07C31/40 ,  C07C31/26

CPC分类号： C07C29/145 ,  C07B2200/07 ,  C07C41/26 ,  C07C2601/08 ,  C07C2601/14 ,  C07C31/20 ,  C07C33/26 ,  C07C35/06 ,  C07C35/08 ,  C07C31/42 ,  C07C43/1785