公开(公告)号：EP0523187A4

公开(公告)日：1994-04-06

申请号：EP91908704

申请日：1991-04-03

申请人： THE SALK INSTITUTE BIOTECHNOLOGY INDUSTRIAL ASSOCIATES, INC.

发明人： HARPOLD, MICHAEL, MILLER ,  ELLIS, STEPHEN, BRADLEY ,  BRUST, PAUL ,  AKONG, MICHAEL ,  VELICELEBI, GONUL

IPC分类号： C07K14/705 ,  C12N15/12 ,  C12Q1/68

CPC分类号： C12Q1/6897 ,  C07K14/70571

摘要： Human neuronal nicotonic acetylcholine receptor subunits are described, as are methods for producing cells containing functional receptors employing such subunits. Also described are assay methods for determining the presence of functional HnAChRs in transfected cells, and for determining the agonist or antagonist activity of compounds with respect to such cells.

摘要翻译： 描述了人神经元尼古丁乙酰胆碱受体亚单位，以及产生含有使用这种亚单位的功能性受体的细胞的方法。 还描述了用于测定转染细胞中功能性HnAChRs的存在和测定化合物对这些细胞的激动剂或拮抗剂活性的测定方法。