专利检索 ap:("THE UNIVERSITY OF MARYLAND AT BALTIMORE") AND inv:"MACKERELL, Alexander, D." 第 1 页

1.

发明公开
INHIBITORS OF THE S100-p53 PROTEIN-PROTEIN INTERACTION AND METHOD OF INHIBITING CANCER EMPLOYING THE SAME 审中-公开
标题翻译：为了降低肿瘤杂志S100 p53的蛋白质 - 蛋白质相互作用和方法的抑制剂使用本抑制剂

公开(公告)号：EP1539248A2

公开(公告)日：2005-06-15

申请号：EP03723795.5

申请日：2003-03-28

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： WEBER, David, J. , MARKOWITZ, Joseph , CARRIER, France , MACKERELL, Alexander, D.

IPC分类号： A61K49/00 , A61K31/415 , A61K31/155 , A61K31/075

CPC分类号： G01N33/5011 , A61K31/00 , A61K31/12 , A61K31/13 , A61K31/15 , A61K31/155 , A61K31/17 , A61K31/185 , A61K31/27 , A61K31/341 , A61K31/4035 , A61K31/4152 , A61K31/435 , A61K31/4425 , A61K31/47 , A61K31/53 , A61K31/553 , A61K31/635

摘要： Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor supressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.

2.

发明公开
IMMUNOMODULATORY COMPOUNDS 审中-公开
标题翻译：免疫调节CONNECTIONS

公开(公告)号：EP1305019A2

公开(公告)日：2003-05-02

申请号：EP01975702.0

申请日：2001-07-31

申请人： THE UNIVERSITY OF MARYLAND AT BALTIMORE

发明人： HAYASHI, Jun , MACKERELL, Alexander, D.

IPC分类号： A61K31/215 , A61K31/12

CPC分类号： A61K31/16 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/21 , A61K31/222 , A61K31/265 , A61K31/4402 , A61K31/47 , A61K31/66

摘要： Compounds are described which modulate the tzrosine kinase activity of p56lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have immunomodulatory activity, e.g., which have immunosuppressant or immunostimulatory activity, and/or which have an antineoplastic effect. The invention further relates to compositions comprising these compounds, and methods of using them.