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1.发明授权5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双（4-脒基苯基）-2,2'- bifuran衍生物和Erwandte化合物作为抗原生动物和前药的活性物质
公开(公告)号：EP1726589B1
公开(公告)日：2008-10-15
申请号：EP06114189.1
申请日：2006-05-19
申请人： The University of North Carolina at Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
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2.发明公开Linear dicationic terphenyls and their aza analogues as antiparasitic agents 审中-公开泰勒尼亚和西班牙语Azaanaloge alsantiparasitäreMittel
公开(公告)号：EP1736466A1
公开(公告)日：2006-12-27
申请号：EP06011533.4
申请日：2006-06-02
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, David W. , Arafa, Reem K.
IPC分类号： C07C257/18 , C07C279/18 , C07D307/68 , C07D213/58 , C07D405/04 , A61K31/435 , A61K31/341 , A61K31/155 , A61P31/04 , C07D239/26 , C07D405/14 , C07D401/14 , C07D213/74
CPC分类号： C07D213/58 , C07C257/18 , C07C259/18 , C07C279/18 , C07D213/74 , C07D213/75 , C07D239/26 , C07D307/54 , C07D307/68 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
摘要翻译： 新型双阳离子三联苯化合物及其杂环类似物。 用新型双阳离子三联苯化合物及其氮杂类似物对抗微生物感染的方法。 合成新型双线性三联苯化合物及其氮杂类似物的方法。
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3.发明公开Linear dicationic terphenyls and their aza analogues as antiparasitic agents 审中-公开线性双阳离子三联苯和它们作为抗寄生虫药氮
公开(公告)号：EP1949896A3
公开(公告)日：2008-08-06
申请号：EP08150205.6
申请日：2008-01-14
申请人： The University of North Carolina At Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , Arafa, Reem K. , Hu, Laixing
IPC分类号： A61K31/155 , C07C257/18 , C07C259/18 , C07C279/18 , C07D213/58 , C07D213/26 , C07D213/28 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/14 , C07D307/46 , C07D307/52 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , A61P33/00
CPC分类号： C07C257/18 , C07C259/18 , C07C279/18 , C07C279/24 , C07D213/58 , C07D239/26 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
L 1 -Ar 1 -(CH 2 ) p -Ar 2 -(CH 2 ) q -Ar 3 -L 2 (I)-
4.发明公开Linear dicationic terphenyls and their aza analogues as antiparasitic agents 审中-公开Lineare dikationische Terphenyle和ihar Azaanaloga alsantiparasitäreMittel
公开(公告)号：EP1949896A2
公开(公告)日：2008-07-30
申请号：EP08150205.6
申请日：2008-01-14
申请人： The University of North Carolina At Chapel Hill , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Ismail, Mohamed A. , Wilson, W. David , Arafa, Reem K. , Hu, Laixing
IPC分类号： A61K31/155 , C07C257/18 , C07C259/18 , C07C279/18 , C07D213/58 , C07D213/26 , C07D213/28 , C07D239/26 , C07D239/28 , C07D241/12 , C07D241/14 , C07D307/46 , C07D307/52 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , A61P33/00
CPC分类号： C07C257/18 , C07C259/18 , C07C279/18 , C07C279/24 , C07D213/58 , C07D239/26 , C07D307/68 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14
摘要： Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
L 1 -Ar 1 -(CH 2 ) p -Ar 2 -(CH 2 ) q -Ar 3 -L 2 (I)摘要翻译： 新型双阳离子三联苯化合物及其杂环类似物。 用新型双阳离子三联苯化合物及其氮杂类似物对抗微生物感染的方法。 合成新型双线性三联苯化合物及其氮杂类似物的方法。 €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒL1 -Ar 1 - （CH 2）p -Ar 2 - （CH 2）q -Ar 3 -L 2€ƒ€ƒ€ƒ€ ƒ（I）
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5.发明公开5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双 - （4-脒基苯基）-2,2'-联呋喃衍生物和作为抗原虫剂的相关化合物及其前药
公开(公告)号：EP1726589A3
公开(公告)日：2006-12-13
申请号：EP06114189.1
申请日：2006-05-19
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
摘要： Novel dicationic bichalcophene compounds of formula (I) are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
wherein:
X 1 and X 2 are independetly selected from the group consisting of O, S, Se, Te, and NR 1 ,
Ar 1 and Ar 2 are independently selected from the group consisting of phenyl, pyridine, and benzimidazole;
Am 1 and Am 2 are each摘要翻译： 描述了新的式（I）的双阳离子双酚类化合物。 目前公开的新型双阳离子双苯乙烯类化合物相对于喷他脒和呋咱英表现出与布氏罗得西亚罗得西亚虫，恶性疟原虫或杜氏利什曼原虫相比的体外活性。 一些新型双阳离子双酚类化合物在布氏锥虫罗得斯菌感染的小鼠模型中显示出良好的体内活性。 其中：X 1和X 2独立地选自O，S，Se，Te和NR 1，Ar 1和Ar 2独立地选自由苯基，吡啶和苯并咪唑组成的组; Am1和Am2都是
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6.发明公开5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof 有权5,5'-双 - （4-脒基苯基）-2,2'-Bifuran衍生物和Erwandte Verbindungen als Wirkstoffe gegen Protozen und Prodrugs
公开(公告)号：EP1726589A2
公开(公告)日：2006-11-29
申请号：EP06114189.1
申请日：2006-05-19
申请人： UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. , Werbovetz, Karl , Brun, Reto
发明人： Werbovetz, Karl , Brun, Reto , Tidwell, Richard R. , Boykin, David W. , Stephens, Chad E. , Ismail, Mohamed A. , Wilson, W. David
IPC分类号： C07D307/68 , C07D405/04 , C07D307/54 , C07D333/24 , C07D345/00 , C07D421/04 , C07C257/18 , C07C259/18 , A61K31/341 , A61K31/443 , A61K31/381 , A61K31/4436 , A61K31/4427 , A61K31/4184 , A61P33/02 , A61P33/06
CPC分类号： C07D307/68 , C07D307/54 , C07D333/24 , C07D333/38 , C07D345/00 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D421/14
摘要： Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium falciparum, or Leishmania donovani comparable to that of pentamidine and furamidine. Some of the novel dicationic bichalcophene compounds displayed good activity in vivo in a murine model of a Trypanosoma brucei rhodesiense infection.
摘要翻译： 描述了式（I）的新型双阳离子双生烯烃化合物。 目前公开的新型双阳离子双生命烯化合物显示体外活性与罗氏黑斑病，恶性疟原虫或杜氏不动症相当，与戊脒和呋脒相当。 一些新型双阳离子双生命烯化合物在罗氏黑斑病感染的鼠模型中在体内表现出良好的活性。 其中：X 1和X 2独立地选自O，S，Se，Te和NR 1，Ar 1和Ar 2独立地选自苯基，吡啶和苯并咪唑; Am 1和Am 2各自
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