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公开(公告)号：EP1918287A3
公开(公告)日：2008-08-20
申请号：EP07122187.3
申请日：2001-03-19
发明人： Miller, Duane , Tigyi, Gabor , Dalton, James , Sardar, Vineet , Elrod, Don , Xu, Huiping , Baker, Daniel , Wang, Dean , Liliom, Karoly , Fischer, David , Virag, Tamas , Nusser, Nora
IPC分类号： C07D327/00 , C07D327/06 , C07F9/06 , C07F9/38 , C07F9/10 , A61K31/66
CPC分类号： C07F9/4028 , A61K31/27 , A61K31/66 , C07F9/091 , C07F9/093 , C07F9/094 , C07F9/098 , C07F9/11 , C07F9/17 , C07F9/222 , C07F9/3808
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors: such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
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公开(公告)号：EP1918287A2
公开(公告)日：2008-05-07
申请号：EP07122187.3
申请日：2001-03-19
发明人： Miller, Duane , Tigyi, Gabor , Dalton, James , Sardar, Vineet , Elrod, Don , Xu, Huiping , Baker, Daniel , Wang, Dean , Liliom, Karoly , Fischer, David , Virag, Tamas , Nusser, Nora
IPC分类号： C07D327/00 , C07D327/06 , C07F9/06 , C07F9/38 , C07F9/10 , A61K31/66
CPC分类号： C07F9/4028 , A61K31/27 , A61K31/66 , C07F9/091 , C07F9/093 , C07F9/094 , C07F9/098 , C07F9/11 , C07F9/17 , C07F9/222 , C07F9/3808
摘要： The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors: such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
摘要翻译： 本发明涉及如本文所公开的根据式（I）的化合物以及包含那些化合物的药物组合物。还公开了使用具有作为LPA受体的激动剂或拮抗剂活性的此类化合物的方法：所述方法包括抑制LPA 对LPA受体的活性，调节LPA受体活性，治疗癌症，增强细胞增殖和治疗伤口。
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