公开(公告)号：EP0967928A4

公开(公告)日：2003-05-21

申请号：EP98911437

申请日：1998-03-06

申请人： THERMOGENESIS CORP ,  NEW YORK BLOOD CT INC

发明人： COELHO PHILIP H ,  RUBINSTEIN PABLO ,  STEVENS CLADD E

IPC分类号： C12M3/06 ,  A01N1/02 ,  A61K35/12 ,  A61K35/28 ,  C12N5/06 ,  A61B19/00 ,  A61M5/32 ,  A61M35/00 ,  B01L3/00 ,  B01L11/00 ,  C12M3/00 ,  C12N5/08

CPC分类号： A01N1/0221 ,  A01N1/02

公开(公告)号：EP0811140A4

公开(公告)日：2002-09-18

申请号：EP96911219

申请日：1996-02-21

申请人： THERMOGENESIS CORP

发明人： COELHO PHILIP H ,  WOLF TERRY ,  RUBINSTEIN PABLO

IPC分类号： B65D81/38 ,  B65G1/00 ,  F25C5/14 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00 ,  F25D23/12

CPC分类号： F25D3/10 ,  F25D3/105 ,  F25D25/00 ,  G01N35/0099

摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

摘要翻译： 用于低温保护耐热产品的装置。 容器（20）容纳由壳体（60）密封的环形齿条（40）。 外壳（60）包括外固定环形（70）和可旋转芯（90）。 机械臂（160）适于移动并被芯（90）支撑。 机械手臂（160）进入外壳（60）的内部。 进入门（80）允许移除和放置受保持器（150）约束的热不稳定产品。 机器人手臂（160）进入产品和支架（150）并开始控制冷冻产品及其在支架（40）中的位置，直到随后的取回。 计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。 机器人臂（160）在存储器中读取产品，以确保访问正确的产品。

公开(公告)号：EP0946225A4

公开(公告)日：2001-10-24

申请号：EP97931114

申请日：1997-06-24

申请人： THERMOGENESIS CORP

发明人： COELHO PHILIP H ,  RUBINSTEIN PABLO

IPC分类号： B65D30/22 ,  A61J1/00 ,  A61J1/05 ,  A61J1/10 ,  A61J1/12 ,  A61J1/14 ,  A61J3/00 ,  A61M1/02 ,  B29C33/00 ,  F25C1/24 ,  A61M5/00 ,  A61M37/00 ,  B29C65/02 ,  B65D33/00

CPC分类号： A61J1/10 ,  A61J1/12 ,  A61M1/0277 ,  B29C65/04 ,  B29C65/08 ,  B29C65/48 ,  B29C66/1312 ,  B29C66/53262 ,  B29C66/54 ,  B29C66/543 ,  B29C66/7394 ,  B29C66/83221 ,  B29L2031/7148 ,  F25C1/243

摘要： A bag (10), method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall (4) for stress relief and to provide the constant cross section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing, so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.

公开(公告)号：EP1012510A4

公开(公告)日：2000-06-28

申请号：EP98932713

申请日：1998-06-15

申请人： THERMOGENESIS CORP ,  NEW YORK BLOOD CENTER INC

发明人： COELHO PHILIP H ,  RUBINSTEIN PABLO ,  WOLF TERRY

IPC分类号： B65D81/38 ,  B65G1/00 ,  B65G1/137 ,  F25C5/14 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00 ,  F25B19/00 ,  F25D23/12

CPC分类号： F25D3/10 ,  F25D3/105 ,  F25D25/00 ,  G01N35/0099

摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

摘要翻译： 低温保护不耐热产品的装置。 容器（20）容纳由外壳（60）密封的环形架（40）。 外壳（60）包括外部固定环面（70）和可旋转芯部（90）。 机器人臂（160）适于移动并由芯（90）支撑。 机器人臂（160）进入外壳（60）的内部。 进入口（80）允许移除和放置由保持器（150）约束的不耐热产品。 机器人臂（160）进入产品和支架（150）并开始对产品及其在机架（40）中的位置进行受控冷冻，直到随后取回。 计算机控制冻结速度并将所有存储产品的位置存储在内存中。 机器人臂（160）读取存储器中的产品以确保正在访问正确的产品。

公开(公告)号：EP1002210A4

公开(公告)日：2000-11-02

申请号：EP98926230

申请日：1998-06-15

申请人： THERMOGENESIS CORP ,  NEW YORK BLOOD CENTER INC

发明人： COELHO PHILIP H ,  RUBINSTEIN PABLO ,  BUCKLEY MARK ,  PELLETIER KEVIN

IPC分类号： B65G1/00 ,  B65G1/137 ,  F17C3/08 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00 ,  F25B19/00 ,  B65G25/00 ,  F25D23/12

CPC分类号： F17C3/085 ,  F17C2201/0119 ,  F17C2201/032 ,  F17C2203/012 ,  F17C2203/0391 ,  F17C2203/0629 ,  F17C2205/052 ,  F17C2205/054 ,  F17C2209/228 ,  F17C2221/014 ,  F17C2223/0161 ,  F17C2250/032 ,  F17C2250/036 ,  F17C2250/0439 ,  F17C2270/0509 ,  F25D3/105 ,  F25D25/00 ,  G01N35/0099

摘要： A system and method for controlled rate freezing and storage of thermolabile substances. The system includes a storage unit (20) for receiving product stored within a bag (180) and an overlying protective canister (110) associated with a robotic arm (60) and reading device which places the canister (110) in the preserving environment. A control system, driven by a computer, monitors the ingress, egress and storage location and particularized profiles of the articles being placed in storage.