公开(公告)号：EP2659881B1

公开(公告)日：2017-11-29

申请号：EP12166110.2

申请日：2012-04-30

申请人： TILLOTTS PHARMA AG

发明人： Bravo Gonzàles, Roberto Carlos ,  Buser, Thomas ,  Goutte, Frédéric Jean-Claude ,  Basit, Abdul Waseh ,  Varum, Felipe José Oliveira ,  Freire, Ana Cristina

IPC分类号： A61K9/00 ,  A61K9/28 ,  A61K31/606 ,  A61K47/32 ,  A61K47/36 ,  A61K31/196 ,  A61K31/616 ,  A61K9/20

CPC分类号： A61K9/2886 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/286 ,  A61K9/2866 ,  A61K9/288 ,  A61K9/2893 ,  A61K31/196 ,  A61K31/606 ,  A61K31/616 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

摘要： Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.

公开(公告)号：EP2659881A1

公开(公告)日：2013-11-06

申请号：EP12166110.2

申请日：2012-04-30

申请人： TILLOTTS PHARMA AG

发明人： Bravo Gonzàles, Roberto Carlos ,  Buser, Thomas ,  Goutte, Frédéric Jean-Claude

IPC分类号： A61K9/00 ,  A61K9/28 ,  A61K31/606 ,  A61K47/32 ,  A61K47/36

CPC分类号： A61K9/2886 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2853 ,  A61K9/286 ,  A61K9/2866 ,  A61K9/288 ,  A61K9/2893 ,  A61K31/196 ,  A61K31/606 ,  A61K31/616 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

摘要： Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.

摘要翻译： 将药物延迟释放到结肠是由包含核心和核心涂层的延迟释放制剂实现的。 核心包括药物，涂层包括内层和外层。 外层包含容易受结肠细菌侵袭的第一聚合物材料和pH值约为pH5或更高的第二聚合物质的混合物。 内层包含可溶于肠液的第三聚合物材料。