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    FERTILITY AGENT
    1.
    发明公开
    FERTILITY AGENT 失效
    FRUCHTBARKEITS-AGENS

    公开(公告)号：EP0790061A1

    公开(公告)日：1997-08-20

    申请号：EP96928679.8

    申请日：1996-08-28

    申请人： TORAY INDUSTRIES, INC.

    发明人： TERAO, Toshihiko ,  KANAYAMA, Naohiro Hamamatsuidaihandayamashukusha ,  NARUTO, Masanobu ,  KANEKO, Tatsuya

    IPC分类号： A61K38/19 ,  A61K38/20 ,  A61K38/21

    CPC分类号： A61K38/195 ,  A61K38/191 ,  A61K38/2006 ,  A61K38/2053 ,  A61K38/217

    摘要： A fertility agent comprising as the active ingredient a leukocyte migration for (interleukin 8, monocyte chemotactic factor, etc.) or a leukocyte migration factor inducer (interleukin 1, tumor necrotizing factor, interferon γ, platelet-activating factor, endotoxin, etc.). The effects of this drug are based on the fact that a leukocyte migration factor or an inducer thereof is efficacious as a single substance in the promotion of both of the growth of an ovum and the implantation of fertilized ovum. It is broadly usable in various industrial fields as a remedy for human and animal infertility and for veterinary and zootechnical purposes of, for example, promoting the production of industrial animals and conserving rare animal species.

    摘要翻译： 包含作为活性成分的白细胞迁移（白细胞介素8，单核细胞趋化因子等）或白细胞迁移因子诱导剂（白细胞介素1，肿瘤坏死因子，干扰素γ，血小板活化因子，内毒素等）的生育剂 。 该药物的作用是基于白细胞迁移因子或其诱导剂作为单一物质有效促进卵子生长和受精卵的植入的事实。 可广泛用于各种工业领域，作为人类和动物不育症以及兽医和动物技术用途的补救方法，例如促进工业动物的生产和保护稀有动物物种。

    SERINE PROTEASE AND SERINE PROTEASE GENE
    3.
    发明授权
    SERINE PROTEASE AND SERINE PROTEASE GENE 失效
    SERIN蛋白酶和蛋白酶SERIN GEN。

    公开(公告)号：EP0307478B1

    公开(公告)日：1995-09-27

    申请号：EP88902211.7

    申请日：1988-02-26

    申请人： TORAY INDUSTRIES, INC.

    发明人： AOKI, Yosuke ,  OKANO, Kiyoshi ,  NARUTO, Masanobu ,  SHIMIZU, Hirohiko ,  NAKAMURA, Haruji

    IPC分类号： C12N9/64 ,  C12N15/00

    CPC分类号： C12N9/6424 ,  C07K2319/00

    摘要： Serine protease showing the bioactivity of a polypeptide having the amino acid sequence, serine protease precursor wherein a splittable peptide or a signal peptide is bound to the N-terminus of the serine protease, and genes coding them are disclosed. Serine protease useful in the medical field can be prepared in a large quantity according to this invention. A DNA sequence which codes a transcription-controlling region contained in a chromosome gene of serine protease of human myeloid cell origin is also disclosed. This sequence is a transcription-controlling region necessary for expression of genes specific to a human leukocyte or erythrocyte system.

    SERINE PROTEASE AND SERINE PROTEASE GENE
    8.
    发明公开
    SERINE PROTEASE AND SERINE PROTEASE GENE 失效
    SERIN-PROTEASE UND SERIN-PROTEASE-GEN。

    公开(公告)号：EP0307478A1

    公开(公告)日：1989-03-22

    申请号：EP88902211.7

    申请日：1988-02-26

    申请人： TORAY INDUSTRIES, INC.

    发明人： AOKI, Yosuke ,  OKANO, Kiyoshi ,  NARUTO, Masanobu ,  SHIMIZU, Hirohiko ,  NAKAMURA, Haruji

    IPC分类号： C12N9/64 ,  C12N15/00

    CPC分类号： C12N9/6424 ,  C07K2319/00

    摘要： Serine protease showing the bioactivity of a polypeptide having the amino acid sequence, serine protease precursor wherein a splittable peptide or a signal peptide is bound to the N-terminus of the serine protease, and genes coding them are disclosed. Serine protease useful in the medical field can be prepared in a large quantity according to this invention. A DNA sequence which codes a transcription-controlling region contained in a chromosome gene of serine protease of human myeloid cell origin is also disclosed. This sequence is a transcription-controlling region necessary for expression of genes specific to a human leukocyte or erythrocyte system.

    摘要翻译： 人类骨髓细胞来源的丝氨酸蛋白酶（长度为238个残基;给出主要结构）; 具有N-末端可裂解或信号肽的序列蛋白酶的前体; 编码丝氨酸蛋白酶和前体的DNA序列; 和用于表达该基因的转录控制DNA序列; 是新的 从人骨髓细胞来源的文库中选择并克隆丝氨酸蛋白酶DNA，插入合适的载体中并在合适的生物如大肠杆菌HMS-174或HB-101或酵母的转化体中表达。