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    PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE FUSED PROTEINS
    5.
    发明公开
    PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE FUSED PROTEINS 失效
    维生素ZUR HERSTELLUNG冯生物学

    公开(公告)号：EP0816510A1

    公开(公告)日：1998-01-07

    申请号：EP96942608.9

    申请日：1996-12-20

    申请人： TORAY INDUSTRIES, INC. ,  TORAY RESEARCH CENTER, INC.

    发明人： NAKATANI, Izumi ,  TOMURA, Michio ,  KANAI, Shozo ,  FUJIWARA, Hiromi ,  AKIYAMA, Hideo

    IPC分类号： C12P21/02 ,  C12N15/62 ,  C12N15/24

    CPC分类号： C07K14/55 ,  A61K38/00 ,  A61K48/00 ,  C07K14/5434 ,  C07K2319/00 ,  C07K2319/75 ,  C12N15/62

    摘要： A process for producing biologically active fused proteins whereby novel biologically active fused proteins usable as a remedy or a diagnostic drug or applicable to gene therapy can be efficiently produced by appropriately selecting the optimum linker polypeptide. This process comprises incubating transformants obtained by the transformation by expression vectors which contain the DNA sequences encoding the amino acid sequences of proteins represented by the following formula: A-X-B wherein A and B represent respectively the subunits of a dimer protein or biologically active proteins and may be the same; and X represents a linker polypeptide.

    摘要翻译： 生产生物活性融合蛋白的方法可以通过适当选择最佳接头多肽来有效地产生可用作补救剂或诊断药物或适用于基因治疗的新型生物活性融合蛋白。 该方法包括通过包含编码由下式表示的蛋白质的氨基酸序列的DNA序列的表达载体孵育获得的转化体：AXB，其中A和B分别代表二聚体蛋白或生物活性蛋白的亚单位，并且可以是 一样; X表示接头多肽。

    SOLUTION FOR EXTRACTION OF RNA
    6.
    发明公开
    SOLUTION FOR EXTRACTION OF RNA 有权
    解RNA提取

    公开(公告)号：EP2607482A1

    公开(公告)日：2013-06-26

    申请号：EP11818210.4

    申请日：2011-08-17

    申请人： Toray Industries, Inc.

    发明人： YOSHIMOTO, Makiko ,  AKIYAMA, Hideo ,  NOBUMASA, Hitoshi

    IPC分类号： C12N15/09

    CPC分类号： C12N15/1003 ,  G01N1/286 ,  G01N2001/2866

    摘要： A solution for extracting substantially pure RNA from a biological sample is disclosed. The solution for extracting RNA from a biological sample containing RNA and at least DNA comprises:
    (a) phenol in an amount of more than 50% by volume based on the total amount of the solution;
    (b) a polyol in an amount of 3 to 10% by volume based on the total amount of the solution;
    (c) a guanidinium salt at a concentration of 0.5 to 2.0 M based on the total amount of the solution;
    (d) a thiocyanate at a concentration of 0.1 to 0.5 M based on the total amount of the solution; and
    (e) a buffer for maintaining the pH of the solution at 4 to 6.

    MATERIALS FOR EXTRACORPOREAL CIRCULATION, ADSORBENTS FOR DIABETIC COMPLICATION FACTORS, CONTAINERS FOR ELIMINATING DIABETIC COMPLICATION FACTORS AND METHOD OF ELIMINATING DIABETIC COMPLICATION FACTORS
    7.
    发明公开
    MATERIALS FOR EXTRACORPOREAL CIRCULATION, ADSORBENTS FOR DIABETIC COMPLICATION FACTORS, CONTAINERS FOR ELIMINATING DIABETIC COMPLICATION FACTORS AND METHOD OF ELIMINATING DIABETIC COMPLICATION FACTORS 审中-公开
    用于体外ZIRKULATIN材料，吸附FOR糖尿病并发症的因素容器距离DIABETSCHER COMPLICATION因素和方法去除糖尿病并发症的因素

    公开(公告)号：EP1219639A1

    公开(公告)日：2002-07-03

    申请号：EP00957072.2

    申请日：2000-09-08

    申请人： TORAY INDUSTRIES, INC.

    发明人： SHIMIZU, Shinji ,  KUBOTA, Masahiro ,  AKIYAMA, Hideo ,  USUI, Mina

    IPC分类号： C07K17/02 ,  C12M1/00 ,  A61M1/02 ,  A61M1/34

    CPC分类号： C07K14/70503 ,  C07K17/02

    摘要： To provide an available adsorbent that can adsorb and remove diabetic complication factors such as carbonyl stress products, a material for use in extracorporeal circulation includes a water-insoluble carrier and a peptide having part or all of a specific receptor amino acid sequence and being immobilized to the water-insoluble carrier. An adsorbent and a method for removing diabetic complication factors are also provided. Such diabetic complication factors may cause arteriosclerosis and other vascular lesions when the carbonyl stress is pathologically enhanced owing to, for example, deteriorated excretion and metabolic functions in diabetes mellitus or artificial dialysis.

    摘要翻译： 提供关于可用的吸附剂也可以吸附除去糖尿病并发症因素：如羰基应激的产品，用于体外循环中使用的材料包括不溶于水的载体和具有部分肽或所有的特异性受体的氨基酸序列，并且被固定到 所述水不溶性载体。 因此，提供的吸附剂和用于去除糖尿病并发症因素的方法。 搜索糖尿病并发症因素可能导致动脉硬化等血管病变当羰应力是由于病理性增强，例如，在糖尿病或人工透析劣化排泄和代谢功能。