公开(公告)号：EP4209228A1

公开(公告)日：2023-07-12

申请号：EP22212373.9

申请日：2016-05-23

申请人： Translational Drug Development, LLC

发明人： WANG, Tong ,  GATELY, Stephen ,  GONZALES, Paul

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K31/4184 ,  C07D235/30 ,  C07D401/04 ,  C07D403/04 ,  A61P35/00 ,  A61P35/04

摘要： The present invention describes a benzamide compound and methods for use thereof, for example in the treatment of cancer. In some implementations, the methods for use including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

公开(公告)号：EP3544601A1

公开(公告)日：2019-10-02

申请号：EP17875035.2

申请日：2017-11-24

申请人： Translational Drug Development, LLC

发明人： WANG, Tong ,  GATELY, Stephen ,  GONZALES, Paul

IPC分类号： A61K31/166 ,  A61K31/4164 ,  A61K31/4184 ,  C07C259/10 ,  C07D235/30

公开(公告)号：EP3718569A1

公开(公告)日：2020-10-07

申请号：EP20159132.8

申请日：2016-05-23

申请人： Translational Drug Development, LLC

发明人： WANG, Tong ,  GATELY, Stephen ,  GONZALES, Paul

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K31/4184 ,  C07D235/30 ,  C07D401/04 ,  C07D403/04 ,  A61P35/00 ,  A61P35/04

摘要： The present invention describes a benzamide compound and methods for use thereof, for example in the treatment of cancer. In some implementations, the methods for use including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.

公开(公告)号：EP3297674A1

公开(公告)日：2018-03-28

申请号：EP16800623.7

申请日：2016-05-23

申请人： TRANSLATIONAL DRUG DEVELOPMENT LLC

发明人： WANG, Tong ,  GATELY, Stephen ,  GONZALES, Paul

IPC分类号： A61K39/395 ,  A61K31/4184 ,  C07D235/30 ,  C07D401/04 ,  C07D403/04

CPC分类号： A61K39/3955 ,  A61K31/4184 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/507 ,  A61K2300/00 ,  A61P35/00 ,  C07D235/30 ,  C07D401/04 ,  C07D403/04 ,  C07K16/2818 ,  C07K2317/76

摘要： The present invention describes compositions, including pharmaceutical compositions, comprising a PD-1 axis binding antagonist, a CTLA4 antagonist, or a DNA demethylating agent and a benzamide compound and methods for use thereof, for example in the treatment of cancer. In some implementations, the methods for use including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.