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公开(公告)号：EP4065583A1
公开(公告)日：2022-10-05
申请号：EP20833977.0
申请日：2020-11-27
发明人： KAWAI, Yuichi , SHIBATA, Kazuaki , ASAKURA, Hiroki , UNO, Takao , SAGARA, Takeshi , NAKAMURA, Masayuki , KOBAYAKAWA, Yu , HOLVEY, Rhian, Sara
IPC分类号： C07D487/08 , C07D491/04 , A61P35/00 , A61K31/519
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公开(公告)号：EP4051266A1
公开(公告)日：2022-09-07
申请号：EP20819899.4
申请日：2020-10-29
发明人： SHIBATA, Kazuaki , KAWAI, Yuichi , ASAKURA, Hiroki , SUGIMOTO, Tetsuya , EGASHIRA, Naoki , YAMAMOTO, Tomohiro , SUZUKI, Tatsuya , KATAOKA, Yuki , SAGARA, Takeshi , SAKAMOTO, Toshihiro , KONDO, Hitomi , HAMLETT, Christopher, Charles, Frederick , SCHÖPF, Patrick , TWIGG, David, Geoffrey
IPC分类号： A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/44 , A61P35/00 , A61P35/02 , C07D201/00
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公开(公告)号：EP4139299A1
公开(公告)日：2023-03-01
申请号：EP21736393.6
申请日：2021-04-23
发明人： KAWAI, Yuichi
IPC分类号： C07D403/12 , C07D403/14 , A61P35/00 , A61K31/551
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公开(公告)号：EP3345907A1
公开(公告)日：2018-07-11
申请号：EP16841868.9
申请日：2016-08-31
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the prevention and/or treatment of a disease involving HER2, particularly, cancer, on the basis of the HER2 inhibitory effect.
The present invention provides a compound of formula (I) wherein X, Y, Z 1 , Z 2 , Z 3 , Z 4 , W, n, R 1 , R 2 , and R 3 have meanings as defined in the present specification, or a salt thereof.-
公开(公告)号：EP2452940B1
公开(公告)日：2014-12-17
申请号：EP10796921.4
申请日：2010-07-09
发明人： KITADE, Makoto , OHKUBO, Shuichi , YOSHIMURA, Chihoko , YAMASHITA, Satoshi , OSHIUMI, Hiromi , UNO, Takao , KAWAI, Yuichi
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04 , C07D209/08 , C07D519/00
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公开(公告)号：EP2452940A1
公开(公告)日：2012-05-16
申请号：EP10796921.4
申请日：2010-07-09
发明人： KITADE, Makoto , OHKUBO, Shuichi , YOSHIMURA, Chihoko , YAMASHITA, Satoshi , OSHIUMI, Hiromi , UNO, Takao , KAWAI, Yuichi
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4709 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P43/00 , C07D519/00
CPC分类号： C07D471/04 , C07D209/08 , C07D519/00
摘要： It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X 1 represents CH or N; any one of X 2 , X 3 and X 4 represents N, and the others represent CH; any one or two of Y 1 , Y 2 , Y 3 and Y 4 represent C-R 4 , and the others are the same or different and represent CH or N; R 1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R 2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R 3 and R 4 represent -CO-R 5 or the like.
摘要翻译： 旨在提供表现出HSP90抑制活性和细胞增殖抑制作用的新型氮杂双环化合物。 具体公开的是由下列通式（I）表示的化合物或其盐：其中X 1表示CH或N; X 2，X 3和X 4中的任一个表示N，其余表示CH; Y 1，Y 2，Y 3和Y 4中的任何一个或两个表示C-R 4，其它相同或不同，表示CH或N; R 1表示具有1至4个选自N，S和O的杂原子的任选取代的单环或双环不饱和杂环基; R 2表示碳原子数1〜6的烷基等。 R 3和R 4表示-CO-R 5等。
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公开(公告)号：EP3345907B1
公开(公告)日：2020-04-22
申请号：EP16841868.9
申请日：2016-08-31
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
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