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公开(公告)号：EP4051266A1
公开(公告)日：2022-09-07
申请号：EP20819899.4
申请日：2020-10-29
发明人： SHIBATA, Kazuaki , KAWAI, Yuichi , ASAKURA, Hiroki , SUGIMOTO, Tetsuya , EGASHIRA, Naoki , YAMAMOTO, Tomohiro , SUZUKI, Tatsuya , KATAOKA, Yuki , SAGARA, Takeshi , SAKAMOTO, Toshihiro , KONDO, Hitomi , HAMLETT, Christopher, Charles, Frederick , SCHÖPF, Patrick , TWIGG, David, Geoffrey
IPC分类号： A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/44 , A61P35/00 , A61P35/02 , C07D201/00
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2.发明公开NOVEL PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME, ESPECIALLY AGENT FOR PREVENTION AND/OR TREATMENT OF TUMORS ETC BASED ON NAE INHIBITORY EFFECT 有权新型PYRROLOPYRIMIDINVERBINDUNG或其盐，药物组合物ORDER，尤其剂预防和/或治疗肿瘤等。 基于NAE锁效果
公开(公告)号：EP3103802A1
公开(公告)日：2016-12-14
申请号：EP15811341.5
申请日：2015-06-24
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P43/00 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： An object to be solved by the present invention is to provide a novel pyrrolopyrimidine compound or a salt thereof having an NAE inhibitory action and a cell growth inhibitory effect. The present invention provides a compound or a salt thereof represented by Formula (A), as well as an NAE inhibitor, a pharmaceutical composition, and an antitumor agent comprising the compound or a salt thereof as an active ingredient.
摘要翻译： 通过本发明要解决的目的是提供一种新颖的吡咯并嘧啶化合物或NAE抑制作用及其具有盐和细胞增殖抑制效果。 本发明提供了包含所述化合物或其盐在其作为活性成分的化合物或由式（A）或其表示的盐，以及以NAE抑制剂，药物组合物，和在抗肿瘤剂。
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3.发明授权NOVEL PYRROLOPYRIMIDINE COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME, ESPECIALLY AGENT FOR PREVENTION AND/OR TREATMENT OF TUMORS ETC BASED ON NAE INHIBITORY EFFECT 有权新的吡咯并嘧啶化合物或其盐，含有该组合物的药物组合物，特别是用于预防和/或治疗基于NAE抑制作用的肿瘤等的药剂
公开(公告)号：EP3103802B1
公开(公告)日：2017-11-08
申请号：EP15811341.5
申请日：2015-06-24
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P43/00 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： An object to be solved by the present invention is to provide a novel pyrrolopyrimidine compound or a salt thereof having an NAE inhibitory action and a cell growth inhibitory effect. The present invention provides a compound or a salt thereof represented by Formula (A), as well as an NAE inhibitor, a pharmaceutical composition, and an antitumor agent comprising the compound or a salt thereof as an active ingredient.
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公开(公告)号：EP4067343A1
公开(公告)日：2022-10-05
申请号：EP19954165.7
申请日：2019-12-06
IPC分类号： C07D205/04
摘要： The present invention provides a phenol compound represented by the following Formula (I) or a salt thereof:
wherein R 1 , R 2 , R 5 , L 1 , L 2 , L 3 , A, X, and m are as described in the specification.-
公开(公告)号：EP3871673A1
公开(公告)日：2021-09-01
申请号：EP19874827.9
申请日：2019-10-25
IPC分类号： A61K31/416 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： An indazole compound represented by the following Formula (I) or a salt thereof:
wherein X, R 1 , R 2 , ring A, L 1 , L 2 , L 3 , and R 5 are as defined in this specification.
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