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公开(公告)号：EP2738163A1
公开(公告)日：2014-06-04
申请号：EP12819674.8
申请日：2012-07-27
发明人： TANIKAWA, Tetsuya , USHIKI, Yasunobu , USHIYAMA, Fumihito , YAMAGUCHI, Toru , ONO, Naoya , YAMAMOTO, Keiko , TSURUTA, Risa , TSUTSUI, Yasuhiro , FUJINO, Noritomo , MORI, Ayumu
IPC分类号： C07D277/28 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P17/00 , A61P31/10 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/04
CPC分类号： C07D417/12 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/04
摘要： The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent. A compound represented by formula (I) (wherein A 1 represents a nitrogen atom or a group represented by formula CR 6 ; A 2 and A 3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R 1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R 2 and R 3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a C 1-6 haloalkyl group or a C 1-6 alkoxy group; and R 4 and R 5 are the same as or different from each other and independently represent a hydrogen atom, a C 1-6 haloalkyl group, a C 1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent.
摘要翻译： 本发明的目的是提供一种对致病真菌具有抗真菌活性的新型化合物，其包括属于假丝酵母属，曲霉属和毛癣菌属的真菌，可用作药剂。 由式（I）表示的化合物（其中A 1表示氮原子或由式CR 6表示的基团; A 2和A 3彼此相同或不同，并且独立地表示氮原子或由 式CH; R 1表示可以被1至5个独立地选自取代基（2）等取代基的取代基取代的芳基; R 2和R 3彼此相同或不同，独立地表示氢 原子，卤素原子，C 1-6烷基，C 1-6卤代烷基或C 1-6烷氧基; R 4和R 5彼此相同或不同，独立地表示氢 原子，C 1-6卤代烷基，C 1-6烷基等）或其盐可用作抗真菌剂。
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公开(公告)号：EP2738163B1
公开(公告)日：2016-01-20
申请号：EP12819674.8
申请日：2012-07-27
发明人： TANIKAWA, Tetsuya , USHIKI, Yasunobu , USHIYAMA, Fumihito , YAMAGUCHI, Toru , ONO, Naoya , YAMAMOTO, Keiko , TSURUTA, Risa , TSUTSUI, Yasuhiro , FUJINO, Noritomo , MORI, Ayumu
IPC分类号： C07D277/28 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P17/00 , A61P31/10 , C07D277/20 , C07D277/30 , C07D277/34 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/04 , C07D417/12
CPC分类号： C07D417/12 , C07D277/20 , C07D277/28 , C07D277/30 , C07D277/34 , C07D277/48 , C07D277/56 , C07D285/08 , C07D417/04
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