利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.017 秒)

    PHYSIOLOGICALLY ACTIVE SUBSTANCES TKR2449, PROCESS FOR PRODUCING THE SAME, AND MICROORGANISM
    1.
    发明公开
    PHYSIOLOGICALLY ACTIVE SUBSTANCES TKR2449, PROCESS FOR PRODUCING THE SAME, AND MICROORGANISM 失效
    生理化学活性物质TKR2449，VERFAHREN ZU IHRER HERSTELLUNG UND MIKROORGANISMEN

    公开(公告)号：EP1002793A1

    公开(公告)日：2000-05-24

    申请号：EP98923171.7

    申请日：1998-06-09

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  UENO, Mitsuhiro ,  AWAZU, Naoyuki 107 Hamoparesu-Kusatsu ,  UNO, Yoko ,  KATO, Ikunoshin

    IPC分类号： C07C233/49 ,  C12P13/02

    CPC分类号： C07C235/76 ,  C12P13/02 ,  Y10S435/911

    摘要： The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders.
    This invention is related to a biologically active substance TKR2449 analog(s) which is represented by the following general formula (A);
    (In the formula, R 1 , R 2 and R 3 are the same or differ each other, and each represents hydrogen or an alkyl group of carbon number of 1 to 4. R 4 is a linear or branched alkyl or alkenyl group of carbon number of 1 to 8.).

    摘要翻译： 本发明的目的是提供新的生物活性物质，其作为真菌感染和免疫病症的治疗剂是有价值的。 本发明涉及由以下通式（A）表示的生物活性物质TKR2449类似物： （式中，R 1，R 2，R 3相同或不同，各自表示氢或碳数为1〜4的烷基。R4为直链或支链的碳数为1〜8的烷基或烯基 为1〜8）。

    METHOD FOR TRANSFERRING GENE INTO GERM CELL
    2.
    发明公开
    METHOD FOR TRANSFERRING GENE INTO GERM CELL 审中-公开
    方法ZURÜBERTRAGUNGEINES GENS IN EINE KEIMZELLE

    公开(公告)号：EP1050586A1

    公开(公告)日：2000-11-08

    申请号：EP99901113.3

    申请日：1999-01-20

    申请人： Takara Shuzo Co, Ltd.

    发明人： UENO, Mitsuhiro ,  KONISHI, Haruko ,  MORISHITA, Mio ,  YUKI, Atsushi ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12N15/86 ,  A01K67/027 ,  C12N5/10

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2800/108

    摘要： Germ cells having a desired foreign gene integrated thereinto; a convenient method for acquiring a vertebrate carrying these cells; and a method for constructing a novel vertebrate line by using these cells and the vertebrate. Namely, a method for transferring a foreign gene into the testes of a vertebrate which involves the step of decreasing a testicular cell number and the step of inoculating a recombinant virus carrying the foreign gene into the testes; the vertebrate having the foreign gene transferred thereinto by the above method; testicular cells obtained from the vertebrate and having the foreign gene transferred thereinto; a vertebrate obtained by mating the above vertebrate and carrying the transferred foreign gene; and a vertebrate obtained by artificial fertilization with the use of the testicular cells and carrying the transferred foreign gene; and a vertebrate obtained by artificial fertilization with the use of the testicular cells and carrying the transferred foreign gene.

    摘要翻译： 具有整合在其中的所需外源基因的生殖细胞; 用于获取携带这些细胞的脊椎动物的方便方法; 以及通过使用这些细胞和脊椎动物构建新的脊椎动物线的方法。 即，将外来基因转移到脊椎动物的睾丸中的方法，其涉及将睾丸细胞数减少的步骤和将携带外来基因的重组病毒接种到睾丸中的步骤; 通过上述方法将外来基因转移到其中的脊椎动物; 从脊椎动物获得并将外源基因转移到其中的睾丸细胞; 通过交配上述脊椎动物并携带转移的外源基因获得的脊椎动物; 和通过使用睾丸细胞进行人工受精并携带转移的外源基因获得的脊椎动物; 以及通过使用睾丸细胞进行人工受精并携带转移的外源基因获得的脊椎动物。

    GENE THERAPEUTICS
    3.
    发明公开
    GENE THERAPEUTICS 有权
    GENTHERAPEUTIKA

    公开(公告)号：EP1163912A1

    公开(公告)日：2001-12-19

    申请号：EP00908055.7

    申请日：2000-03-14

    申请人： Takara Shuzo Co, Ltd.

    发明人： KATO, Ikunoshin ,  ASADA, Kiyozo ,  UENO, Mitsuhiro ,  HASHINO, Kimikazu ,  YOSHIOKA, Hirofumi, 311, Hamoparesu-Kusatsu ,  TANAKA, Keiji

    IPC分类号： A61K48/00

    CPC分类号： A61K48/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2740/13043 ,  C12N2810/40

    摘要： Gene therapeutics to be used in treating diseases showing sensitivity to gene therapy, characterized by containing as the active ingredient an efficacious amount of a functional substance which has a function of having an affinity for a virus containing a gene usable in the gene therapy and another function of having an affinity specific for a target cell with a need for the gene transfer, or an efficacious amount of a functional substance which has an affinity for the above virus and an efficacious amount of another functional substance which has an affinity specific for the above cell.

    摘要翻译： 用于治疗对基因治疗具有敏感性的疾病的基因疗法，其特征在于，含有作为活性成分的有效量的具有对含有可用于基因治疗的基因的病毒具有亲和力的功能物质和另一功能 对具有基因转移需要的靶细胞具有亲和力的有效量的对上述病毒具有亲和力的有效量的功能物质和对上述细胞具有亲和力的有效量的另一种功能性物质 。

    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE
    5.
    发明公开
    ANTIBIOTIC TKR2999, PROCESS FOR THE PREPARATION THEREOF AND MICROBE 有权
    抗生素TKR2999，VERFAHREN ZUR HERSTELLUNG DESSELBEN SOWIE MIKROBE

    公开(公告)号：EP1044983A1

    公开(公告)日：2000-10-18

    申请号：EP98963649.3

    申请日：1998-12-22

    申请人： Takara Shuzo Co, Ltd.

    发明人： TAKESAKO, Kazutoh ,  AWAZU, Naoyuki ,  UENO, Mitsuhiro ,  ONISHI, Yoshimi ,  KATO, Ikunoshin

    IPC分类号： C07G11/00 ,  C12P1/02 ,  C12N1/14

    CPC分类号： C12R1/645 ,  A61K38/00 ,  C07K4/06 ,  C12P21/02

    摘要： The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt:
    (1) FAB-MS m/z 971 [M+H] + , (2) the molecular formula: C 44 H 78 N 10 O 14 , and high-resolution FAB-MS m/z 971.5776 [M+H] + , (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm -1 , (5) aspartic acid, threonine, serine, glycine, alanine, β-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
    The novel antibiotic is useful as a therapeutic agent for fungal infection diseases.

    摘要翻译： 具有下述物理化学性质的抗生素TKR2999及其药理学上可接受的盐：（1）FAB-MS m / z 971ÄM+HÜ+，（2）分子式：C44H78N10O14和高分辨率FAB-MS m / z 971.5776ÄM+HÜ+，（3）甲醇中的紫外吸收光谱具有终点吸收，（4）通过KBr方法的红外吸收光谱显示了3320,2920,1680,1540,1210,1600,1540,1410,1440,1540,1410,1440,1480,1540,1410,1440,1480,1440,1480,1440,1480,1440,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,14 1140,840,800和720cm -1，（5）通过使用茚三酮反应的氨基酸分析检测天冬氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，β-丙氨酸和鸟氨酸，和（6） 溶解度是溶于甲醇，几乎不溶于己烷，氯仿和水。 新型抗生素可用作真菌感染疾病的治疗剂。

    GENE TRANSFER METHOD
    6.
    发明公开
    GENE TRANSFER METHOD 有权
    GENTRANSFERVERFAHREN

    公开(公告)号：EP1225229A1

    公开(公告)日：2002-07-24

    申请号：EP00969984.4

    申请日：2000-10-23

    申请人： Takara Shuzo Co, Ltd.

    发明人： UENO, Takashi, 609, Hamoparesu-Kusatsu ,  MATSUMURA, Hajime ,  TANAKA, Keiji ,  IWASAKI, Tomoko ,  UENO, Mitsuhiro ,  FUJINAGA, Kei ,  ASADA, Kiyozo ,  KATO, Ikunoshin

    IPC分类号： C12N15/861 ,  A61K35/12 ,  A61K35/76 ,  A61K48/00 ,  C12N5/10 ,  C12N7/01

    CPC分类号： C12N15/86 ,  C12N2710/10343 ,  C12N2800/30

    摘要： A method of transferring a foreign gene into cells, characterized by involving: the step of transferring into the cells with the use of an adenovirus vector, a first nucleic acid, which has a sequence provided with adeno-associated virus-origin ITRs in both sides of the target foreign gene to be transferred, and a second nucleic acid, which has an adeno-associated virus-origin rep gene and a promoter for expressing this gene and carries a stuffer sequence inserted thereinto sandwiched in two recombinase recognition sequences and located between the rep gene and the promoter; and the step of expressing the Rep protein under the action of recombinase in the cells obtained in the above step to thereby integrate the target foreign gene into the chromosomal DNA.

    摘要翻译： 将外源基因转移到细胞中的方法，其特征在于包括：使用腺病毒载体转移到细胞中的步骤，第一核酸，其具有在两侧具有腺相关病毒起源ITR的序列 的待转移的靶外源基因的第二核酸和具有腺相关病毒起源rep基因的第二核酸和用于表达该基因并携带插入其中的填充序列的第二核酸夹在两个重组酶识别序列中并位于 rep基因和启动子; 以及在上述步骤中获得的细胞中在重组酶的作用下表达Rep蛋白的步骤，从而将靶外源基因整合到染色体DNA中。