公开(公告)号：EP1044983A1

公开(公告)日：2000-10-18

申请号：EP98963649.3

申请日：1998-12-22

申请人： Takara Shuzo Co, Ltd.

发明人： TAKESAKO, Kazutoh ,  AWAZU, Naoyuki ,  UENO, Mitsuhiro ,  ONISHI, Yoshimi ,  KATO, Ikunoshin

IPC分类号： C07G11/00 ,  C12P1/02 ,  C12N1/14

CPC分类号： C12R1/645 ,  A61K38/00 ,  C07K4/06 ,  C12P21/02

摘要： The antibiotic TKR2999 having the physicochemical properties described below and its pharmacologically acceptable salt:
(1) FAB-MS m/z 971 [M+H] + , (2) the molecular formula: C 44 H 78 N 10 O 14 , and high-resolution FAB-MS m/z 971.5776 [M+H] + , (3) the ultraviolet absorption spectrum in methanol has an end absorption, (4) the infrared absorption spectrum by KBr method shows the major absorption wave numbers at 3320, 2920, 1680, 1540, 1210, 1140, 840, 800, and 720 cm -1 , (5) aspartic acid, threonine, serine, glycine, alanine, β-alanine, and ornithine are detected by the amino acid analysis using ninhydrin reaction, and (6) the solubility is that it is soluble in methanol, and practically insoluble in hexane, chloroform, and water.
The novel antibiotic is useful as a therapeutic agent for fungal infection diseases.

摘要翻译： 具有下述物理化学性质的抗生素TKR2999及其药理学上可接受的盐：（1）FAB-MS m / z 971ÄM+HÜ+，（2）分子式：C44H78N10O14和高分辨率FAB-MS m / z 971.5776ÄM+HÜ+，（3）甲醇中的紫外吸收光谱具有终点吸收，（4）通过KBr方法的红外吸收光谱显示了3320,2920,1680,1540,1210,1600,1540,1410,1440,1540,1410,1440,1480,1540,1410,1440,1480,1440,1480,1440,1480,1440,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,1480,14 1140,840,800和720cm -1，（5）通过使用茚三酮反应的氨基酸分析检测天冬氨酸，苏氨酸，丝氨酸，甘氨酸，丙氨酸，β-丙氨酸和鸟氨酸，和（6） 溶解度是溶于甲醇，几乎不溶于己烷，氯仿和水。 新型抗生素可用作真菌感染疾病的治疗剂。

公开(公告)号：EP0955366A1

公开(公告)日：1999-11-10

申请号：EP96941211.3

申请日：1996-12-10

申请人： TAKARA SHUZO CO. LTD.

发明人： TAKESAKO, Kazutoh ,  OKADO, Takashi ,  YAGIHARA, Tomoko ,  KURODA, Masanobu ,  ONISHI, Yoshimi ,  KATO, Ikunoshin ,  AKIYAMA, Kazuo ,  YASUEDA, Hiroshi ,  YAMAGUCHI, Hideyo

IPC分类号： C12N15/31 ,  C07K14/37 ,  C07K16/14 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/53 ,  A61K39/00

CPC分类号： A61K39/0002 ,  A61K38/00 ,  A61K39/00 ,  C07K14/37 ,  C07K16/14 ,  Y10S530/858

摘要： A substantially pure, isolated, antigenic protein from fungi of the genus
Malassezia , characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from
Malassezia , antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for
Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.