-
公开(公告)号：EP0366016A2
公开(公告)日：1990-05-02
申请号：EP89119505.9
申请日：1989-10-20
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same.
Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3.
Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.摘要翻译： 公开了（1）含有编码内皮素-2或人内皮素-3的DNA区段的DNA序列，（2）前体蛋白质和内皮素-2或人内皮素-3的成熟肽，（3）携带 含有编码内皮素-2或人内皮素-3的DNA区段的DNA序列和（4）制备成熟内皮素-2或内皮素-3的方法，其包括培养（3）中所述的转化体，产生和积累蛋白质 培养基，并收集。 用DNA转染或转化的细胞允许产生大量的内皮素-2或内皮素-3，这导致有利地产生内皮素-2或内皮素-3。 内皮素-2和内皮缩血管素-3可用作包括人在内的动物的低血压治疗剂或局部血管收缩剂。
-
公开(公告)号：EP0366016B1
公开(公告)日：1994-04-13
申请号：EP89119505.9
申请日：1989-10-20
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
-
公开(公告)号：EP0543425B1
公开(公告)日：2000-01-12
申请号：EP92120602.5
申请日：1989-10-20
IPC分类号： C12N15/16 , C12P21/02 , C07K14/575
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
-
公开(公告)号：EP0543425A1
公开(公告)日：1993-05-26
申请号：EP92120602.5
申请日：1989-10-20
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Disclosed are (1) a DNA sequence containing a DNA segment coding for human endothelin-3, (2) a precursor protein and a mature peptide of human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for human endothelin-3 and (4) a method for preparing mature endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same. Cells transfected or transformed with the DNA allow large amounts of endothelin-3 to be produced, which causes the advantageous production of endothelin-3.
Endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.摘要翻译： 公开了（1）含有编码人内皮素-3的DNA区段的DNA序列，（2）前体蛋白质和人内皮素-3的成熟肽，（3）携带含有编码 人内皮素-3和（4）制备成熟内皮素-3的方法，其包括培养（3）中所述的转化体，在培养基中产生和积累蛋白质，并收集其中。 用DNA转染或转化的细胞允许产生大量的内皮素-3，这导致内皮素-3的有利产生。 内皮素-3可用作包括人在内的动物的低血压治疗剂或局部血管收缩剂。
-
公开(公告)号：EP0366016A3
公开(公告)日：1990-08-01
申请号：EP89119505.9
申请日：1989-10-20
CPC分类号： C07K14/57536 , A61K38/00 , Y10S930/26
摘要： Disclosed are (1) a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3, (2) a precursor protein and a mature peptide of endothelin-2 or human endothelin-3, (3) a transformant carrying a DNA sequence containing a DNA segment coding for endothelin-2 or human endothelin-3 and (4) a method for preparing mature endothelin-2 or endothelin-3 which comprises culturing the transformant described in (3), producing and accumulating a protein in a culture medium, and collecting the same. Cells transfected or transformed with the DNA allow large amounts of endothelin-2 or endothelin-3 to be produced, which causes the advantageous production of endothelin-2 or endothelin-3. Endothelin-2 and endothelin-3 can be utilized as hypotension therapeutic agents or local vasoconstrictors to animals including humans.
-
-
-
-
搜索结果
5 条记录 (耗时 0.011 秒)
