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37 条记录 (耗时 0.017 秒)

    Coumaran derivatives, their production and use
    5.
    发明公开
    Coumaran derivatives, their production and use 失效
    2,3-Dihydro-Cumaron-Derivate，ihre Herstellung und Verwendung。

    公开(公告)号：EP0273647A1

    公开(公告)日：1988-07-06

    申请号：EP87311122.3

    申请日：1987-12-17

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Terao, Shinji ,  Maki, Yoshitaka

    IPC分类号： C07D307/83 ,  C07D405/04 ,  A61K31/34 ,  A61K31/44

    CPC分类号： C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D307/94 ,  C07D405/04

    摘要： A compound of the formula
    wherein R is a lower alkyl group, R 0 is hydrogen or an acyl group, R 1 and R 2 are lower alkyl groups which may optionally be substituted or wherein R 1 and R 2 are combined to form a butadienylene group which may optionally be substituted, R 3 and R 4 are hydrogen or alkyl groups which may 'optionally be substituted or wherein R 3 and R 4 are combined to form a polymethylene group, and R 5 is a lower alkyl, aromatic or heterocyclic group which may optionally be substituted or a pharmaceutically acceptable salt thereof, exerts cardiovascular system improving action and antiallergic action and can be used as pharmaceutics, e.g. antithromotics, antiallergic agents etc.

    摘要翻译： 式CHEM的化合物，其中R为低级烷基，R 0为氢或酰基，R 1和R 2为可任选被取代的低级烷基或R 1为 >和R 2结合形成可任选被取代的亚丁二烯基，R 3和R 4是氢或可任选被取代的或其中R 3和R 4的烷基是 组合形成多亚甲基，R 5为可任选取代的低级烷基，芳族或杂环基或其药学上可接受的盐，发挥心血管系统改善作用和抗过敏作用，可用作药物，例如 抗血栓药，抗过敏剂等

    Quinone compounds, their production and use
    8.
    发明公开
    Quinone compounds, their production and use 失效
    Chinonverbindungen，ihre Herstellung und Verwendung。

    公开(公告)号：EP0103361A1

    公开(公告)日：1984-03-21

    申请号：EP83303715.3

    申请日：1983-06-28

    申请人： Takeda Chemical Industries, Ltd.

    发明人： Terao, Shinji ,  Maki, Yoshitaka

    IPC分类号： C07C50/38 ,  C07C59/82 ,  C07C69/95 ,  C07C46/06 ,  A61K31/12 ,  A61K31/19 ,  A61K31/215

    CPC分类号： C07D309/12 ,  C07C46/00 ,  C07C50/38 ,  C07C66/00

    摘要： New quinone compounds of the formula:
    wherein

    R is methyl or methoxy and
    Y is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or dialkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, or their hydroquinone-form compounds, or pharmaceutically acceptable salts thereof, have useful physiological activities such as antiasthmatic and antiallergic activities.

    摘要翻译： 新的具有下式的醌化合物：其中R是甲基或甲氧基，Y是甲酰基，羧基，具有2至5个碳原子的烷氧基羰基，氨基甲酰基，一或二烷基氨基甲酰基，其烷基部分具有1至4个碳原子或氨基甲酰氧基甲基 或其氢醌形式的化合物或其药学上可接受的盐具有有用的生理活性，例如抗哮喘和抗过敏活性。