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公开(公告)号：EP0202065A3
公开(公告)日：1987-10-21
申请号：EP86303417
申请日：1986-05-06
CPC分类号： C08G63/06 , A61K9/1647 , A61K9/5031 , B01J13/125 , Y10S514/937
摘要： The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer. The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an excipient for pharmaceutical preparations.
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公开(公告)号：EP0202065A2
公开(公告)日：1986-11-20
申请号：EP86303417.9
申请日：1986-05-06
CPC分类号： C08G63/06 , A61K9/1647 , A61K9/5031 , B01J13/125 , Y10S514/937
摘要： The present invention provides a biodegradable high molecular polymer characterized in that the content of water-soluble low molecular compounds, as calculated on the assumption that each of said compounds is a monobasic acid, is less than 0.01 mole per 100 grams of said high molecular polymer.
The thus-obtained high molecular polymer has good aging stability and can be used advantageously as an excipient for pharmaceutical preparations.-
公开(公告)号：EP0551169A1
公开(公告)日：1993-07-14
申请号：EP93300007.7
申请日：1993-01-04
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1277
摘要： A liposome composition in which an aqueous solution containing a water-soluble drug in saturated concentration or more at ordinary temperature is encapsulated in liposomes is disclosed. The liposome composition is produced by forming a liposome membrane under warming by using as a solution to be encapsulated an aqueous solution containing a water-soluble drug in saturated concentration or more at ordinary temperature.
摘要翻译： 公开了一种脂质体组合物，其中含有在常温下饱和浓度或更高浓度的水溶性药物的水溶液被包封在脂质体中。 脂质体组合物通过在常温下使用含有饱和浓度以上的水溶性药物的水溶液作为溶液形成脂质体膜而制成。
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公开(公告)号：EP0190833B1
公开(公告)日：1991-03-27
申请号：EP86300308.3
申请日：1986-01-17
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , B01J13/02 , Y10S514/80 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
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公开(公告)号：EP0178824A1
公开(公告)日：1986-04-23
申请号：EP85307083.7
申请日：1985-10-03
CPC分类号： C08G63/90 , C08G85/002 , C08J3/14
摘要： A formed product of a high molecular compound having a glass transition temperature of not more than about 60°C, which is substantially free of halogenated solvents harmful to the human body, is produced by mixing the high molecular compound, a halogenated solvent and an organic solvent other than the halogenated solvent which is compatible with the solvent and is less apt to dissolve the high molecular compound to prepare a solution and then maintaining the solution at a temperature around the boiling point of the halogenated solvent.
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公开(公告)号：EP0202065B1
公开(公告)日：1993-04-07
申请号：EP86303417.9
申请日：1986-05-06
CPC分类号： C08G63/06 , A61K9/1647 , A61K9/5031 , B01J13/125 , Y10S514/937
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公开(公告)号：EP0190833A3
公开(公告)日：1987-08-26
申请号：EP86300308
申请日：1986-01-17
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , B01J13/02 , Y10S514/80 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： Microcapsules are advantageously produced with a high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/0 emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.
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公开(公告)号：EP0190833A2
公开(公告)日：1986-08-13
申请号：EP86300308.3
申请日：1986-01-17
CPC分类号： A61K9/5031 , A61K9/1647 , A61K9/1652 , A61K9/1658 , A61K9/1694 , B01J13/02 , Y10S514/80 , Y10S514/885 , Y10S514/963 , Y10T428/2984 , Y10T428/2985 , Y10T428/2987
摘要： Microcapsules are advantageously produced with a high take-up of a water-soluble drug by preparing a W/O emulsion composed of a water-soluble drug-containing solution as the inner aqueous phase and a polymer-containing solution as the oil phase, dispersing said emulsion in an aqueous phase and subjecting the resulting W/O/W emulsion to an in-water drying, wherein the viscosity of the W/0 emulsion used in preparing the W/O/W emulsion is adjusted to about 150 to about 10,000 centipoises.
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